Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8858347 | 0.84 | HTR1A (0.47) | HTR1ADRD2DRD3SMN1; SMN2KDM4E | |
| SCHEMBL8858346 | 0.84 | HTR1A (0.47) | HTR1ADRD2DRD3SMN1; SMN2KDM4E | |
| SCHEMBL1388879 | 0.73 | DRD2 (0.44) | HTR1AALDH1A1HSD17B10DRD2DRD3 | |
| SCHEMBL11805239 | 0.72 | SIGMAR1 (0.47) | ALDH1A1DRD2RAB9ASIGMAR1KDM4E | |
| SCHEMBL11805236 | 0.72 | SIGMAR1 (0.47) | ALDH1A1DRD2RAB9ASIGMAR1KDM4E | |
| SCHEMBL8791055 | 0.71 | MAOA (0.45) | HTR1ADRD2DRD3RAB9ASIGMAR1 | |
| SCHEMBL8858349 | 0.71 | MAOA (0.45) | HTR1ADRD2DRD3RAB9ASIGMAR1 | |
| SCHEMBL8858342 | 0.70 | DRD2 (0.48) | HTR1ADRD2DRD3RAB9ASIGMAR1 | |
| SCHEMBL8858344 | 0.70 | DRD2 (0.48) | HTR1ADRD2DRD3RAB9ASIGMAR1 | |
| SCHEMBL11793066 | 0.68 | SIGMAR1 (0.40) | ALDH1A1RAB9ASIGMAR1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-H09512542-A | — | — | 1997-12-16 | — | — | JP | claimed |
| EP-0757686-A1 | BENZOFURAN DERIVATIVES AS D 4? RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1997-02-12 | — | — | EP | claimed |
| WO-1995029911-A1 | BENZOFURAN DERIVATIVES AS D4 RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-11-09 | — | — | WO | claimed |