Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13306868 | 0.90 | ALDH1A1 (0.48) | TSHRUSP2ALOX15SMN1; SMN2ALDH1A1 | |
| SCHEMBL13889793 | 0.85 | TSHR (0.55) | TSHRUSP2ALOX15SMN1; SMN2ALDH1A1 | |
| SCHEMBL13307028 | 0.82 | TSHR (0.52) | TSHRUSP2ALOX15SMN1; SMN2ALDH1A1 | |
| SCHEMBL13307016 | 0.81 | SMN1; SMN2 (0.52) | TSHRUSP2ALOX15SMN1; SMN2ALDH1A1 | |
| SCHEMBL13306870 | 0.81 | TSHR (0.51) | TSHRUSP2ALOX15SMN1; SMN2ALDH1A1 | |
| SCHEMBL13306949 | 0.80 | TSHR (0.50) | TSHRUSP2ALOX15SMN1; SMN2ALDH1A1 | |
| SCHEMBL13306872 | 0.80 | TSHR (0.50) | TSHRUSP2ALOX15SMN1; SMN2ALDH1A1 | |
| SCHEMBL13307014 | 0.80 | USP2 (0.49) | TSHRUSP2ALOX15SMN1; SMN2ALDH1A1 | |
| SCHEMBL13306861 | 0.72 | TSHR (0.57) | TSHRUSP2ALOX15SMN1; SMN2ALDH1A1 | |
| SCHEMBL13404432 | 0.69 | ADRA1D (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090111801-A1 | SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE AS A MEDICINE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-30 | — | — | US | disclosed |
| US-20090111801-A1 | SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE AS A MEDICINE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111801-A1 | SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE AS A MEDICINE | ADRA2C, ADRB2, CHRNA5 | TSHR 2075/4885USP2 4796/4885ALOX15 1608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.