Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13307028 | 0.89 | TSHR (0.52) | TSHRSMN1; SMN2USP2ALOX15ALDH1A1 | |
| SCHEMBL13306870 | 0.88 | TSHR (0.51) | TSHRSMN1; SMN2USP2ALOX15ALDH1A1 | |
| SCHEMBL13306949 | 0.87 | TSHR (0.50) | TSHRSMN1; SMN2USP2ALOX15ALDH1A1 | |
| SCHEMBL13306872 | 0.87 | TSHR (0.50) | TSHRSMN1; SMN2USP2ALOX15ALDH1A1 | |
| SCHEMBL13307014 | 0.86 | USP2 (0.49) | TSHRSMN1; SMN2USP2ALOX15ALDH1A1 | |
| SCHEMBL13307016 | 0.86 | SMN1; SMN2 (0.52) | TSHRSMN1; SMN2USP2ALOX15ALDH1A1 | |
| SCHEMBL13889591 | 0.85 | TSHR (0.47) | TSHRSMN1; SMN2USP2ALOX15ALDH1A1 | |
| SCHEMBL13306868 | 0.84 | ALDH1A1 (0.48) | TSHRSMN1; SMN2USP2ALOX15ALDH1A1 | |
| SCHEMBL13889594 | 0.79 | ALDH1A1 (0.46) | TSHRSMN1; SMN2USP2ALOX15ALDH1A1 | |
| SCHEMBL13404501 | 0.78 | HTR3E (0.54) | TSHRALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090111801-A1 | SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE AS A MEDICINE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111801-A1 | SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE AS A MEDICINE | ADRA2C, ADRB2, CHRNA5 | TSHR 2075/4885SMN1; SMN2 432/4885USP2 4796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.