Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | STAT3 | P40763 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | FPR1 | P21462 | 1/20 | 0.35 |
| ▸ | GPR183 | P32249 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | GLP1R | P43220 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5231461 | 0.85 | HPGD (0.42) | KDM4EHPGDLMNASTAT3NPSR1 | |
| SCHEMBL13891759 | 0.85 | TACR1 (0.37) | TACR1ADRB2FPR1GPR183APLNR | |
| SCHEMBL13891738 | 0.85 | TACR1 (0.41) | KDM4ELMNASTAT3NPSR1MITF | |
| SCHEMBL13891616 | 0.85 | SDHB (0.40) | TACR1PTGS2ADRB2FPR1GPR183 | |
| SCHEMBL13891766 | 0.83 | KDM4E (0.38) | KDM4EHPGDLMNATACR1HSD17B10 | |
| SCHEMBL5530937 | 0.82 | CETP (0.39) | KDM4EHPGDLMNATACR1HSD17B10 | |
| SCHEMBL5532435 | 0.80 | GPBAR1 (0.47) | TACR1CETPADRB2FPR1GPR183 | |
| SCHEMBL13891740 | 0.78 | TLR7 (0.36) | L3MBTL1MEN1TSHRKMT2ASDHB | |
| SCHEMBL5534321 | 0.77 | NPC1 (0.38) | HPGDLMNAHTTTACR1SMN1; SMN2 | |
| SCHEMBL13891760 | 0.77 | TACR1 (0.41) | TACR1ADRB2FPR1GPR183APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1473295-B1 | FUSED BICYCLIC PYRIMIDINE DERIVATIVES | KYORIN SEIYAKU KK (JP) | 2009-04-01 | — | — | EP | disclosed |