Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | SDHB | P21912 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | CLPP | Q16740 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | DHPS | P49366 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13891686 | 0.85 | MAPT (0.35) | MEN1KMT2AKCNH2GRM2MAPK14 | |
| SCHEMBL13891616 | 0.83 | SDHB (0.40) | SDHB | |
| SCHEMBL13891767 | 0.79 | P2RX3 (0.40) | MEN1KMT2AL3MBTL1CYP2C9 | |
| SCHEMBL13891759 | 0.79 | TACR1 (0.37) | P2RX7 | |
| SCHEMBL13891702 | 0.78 | KDM4E (0.41) | SDHBMEN1KMT2AL3MBTL1TSHR | |
| SCHEMBL13891760 | 0.74 | TACR1 (0.41) | — | |
| SCHEMBL5232743 | 0.73 | TACR1 (0.40) | SDHBL3MBTL1CYP3A4CYP2D6 | |
| SCHEMBL13891721 | 0.73 | HTT (0.37) | MEN1KMT2AL3MBTL1CYP2C9 | |
| SCHEMBL13891738 | 0.73 | TACR1 (0.41) | MEN1KMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5225462 | 0.73 | SDHB (0.40) | SDHB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1473295-B1 | FUSED BICYCLIC PYRIMIDINE DERIVATIVES | KYORIN SEIYAKU KK (JP) | 2009-04-01 | — | — | EP | disclosed |