Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | AGER | Q15109 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TACR1 | P25103 | 6/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5231442 | 0.86 | ALDH1A1 (0.39) | KDM4EMAPTL3MBTL1AGERLMNA | |
| SCHEMBL13891702 | 0.83 | KDM4E (0.41) | KDM4EMAPTL3MBTL1AGERLMNA | |
| SCHEMBL13891687 | 0.83 | PIK3R1 (0.41) | KDM4EMAPTL3MBTL1AGERLMNA | |
| SCHEMBL13891717 | 0.81 | ADRB2 (0.43) | KDM4EMAPTL3MBTL1AGERLMNA | |
| SCHEMBL13891719 | 0.81 | TACR1 (0.48) | TACR1ROCK2ROCK1CASP1CASP5 | |
| SCHEMBL13891764 | 0.80 | PIK3R1 (0.38) | KDM4EMAPTL3MBTL1AGERLMNA | |
| SCHEMBL5530937 | 0.80 | CETP (0.39) | KDM4EMAPTL3MBTL1AGERLMNA | |
| SCHEMBL29373661 | 0.79 | TACR1 (0.44) | TSHRHPGDTACR1PIK3R1MTOR | |
| SCHEMBL6508415 | 0.79 | TACR1 (0.44) | TSHRHPGDTACR1PIK3R1MTOR | |
| SCHEMBL13891704 | 0.78 | PIK3R1 (0.46) | MAPTL3MBTL1LMNAMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1473295-B1 | FUSED BICYCLIC PYRIMIDINE DERIVATIVES | KYORIN SEIYAKU KK (JP) | 2009-04-01 | — | — | EP | disclosed |