Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 11/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.46 |
| ▸ | TACR1 | P25103 | 4/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP5 | P51878 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13891619 | 0.90 | MTOR (0.47) | MTORPIK3R1TACR1PIK3CAPIK3CG | |
| SCHEMBL13891704 | 0.89 | PIK3R1 (0.46) | MTORPIK3R1TACR1PIK3CACASP1 | |
| SCHEMBL13891717 | 0.82 | ADRB2 (0.43) | MTORPIK3R1TACR1PIK3CACASP1 | |
| SCHEMBL13891705 | 0.82 | MTOR (0.38) | MTORPIK3R1TACR1PIK3CAPIK3CG | |
| SCHEMBL13891764 | 0.82 | PIK3R1 (0.38) | MTORPIK3R1TACR1PIK3CACASP1 | |
| SCHEMBL13891687 | 0.80 | PIK3R1 (0.41) | MTORPIK3R1TACR1CASP1CASP5 | |
| SCHEMBL13891713 | 0.76 | TACR1 (0.42) | TACR1ROCK2ROCK1 | |
| SCHEMBL13891738 | 0.76 | TACR1 (0.41) | TACR1ROCK2ROCK1 | |
| SCHEMBL13891719 | 0.74 | TACR1 (0.48) | TACR1CASP1CASP5BRAFROCK2 | |
| SCHEMBL6508415 | 0.74 | TACR1 (0.44) | MTORPIK3R1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1473295-B1 | FUSED BICYCLIC PYRIMIDINE DERIVATIVES | KYORIN SEIYAKU KK (JP) | 2009-04-01 | — | — | EP | disclosed |