Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.49 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10320930 | 0.79 | PLOD2 (0.89) | ALDH1A1PLOD2CYP3A4MAPTCYP2C9 | |
| SCHEMBL29554726 | 0.79 | PLOD2 (0.89) | ALDH1A1PLOD2CYP3A4MAPTCYP2C9 | |
| SCHEMBL31661891 | 0.77 | MEN1 (0.61) | ALDH1A1CYP3A4MAPTCYP2C9PKM | |
| SCHEMBL82139 | 0.76 | PLOD2 (0.67) | ALDH1A1PLOD2CYP3A4MAPTKMT2A | |
| SCHEMBL30489909 | 0.76 | PLOD2 (0.67) | ALDH1A1PLOD2CYP3A4MAPTKMT2A | |
| Methyl Nicotinate SCHEMBL29386553 | 0.76 | ALDH1A1 (1.00) | ALDH1A1KMT2ALMNAHPGDHSD17B10 | |
| Methyl Nicotinate SCHEMBL24566 | 0.76 | ALDH1A1 (1.00) | ALDH1A1KMT2ALMNAHPGDHSD17B10 | |
| Methyl Nicotinate SCHEMBL820747 | 0.76 | ALDH1A1 (1.00) | ALDH1A1KMT2ALMNAHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL6946997 | 0.75 | PLOD2 (0.65) | ALDH1A1PLOD2CYP3A4MAPTKMT2A | |
| SCHEMBL15390076 | 0.74 | KMT2A (0.69) | ALDH1A1PLOD2MAPTPKMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7501446-B2 | Prenylation inhibitors and methods of their synthesis and use | PPD DISCOVERY, INC. (US) | 2009-03-10 | — | — | US | disclosed |
| US-20070149549-A1 | 3-(Pyrid-3-yl)-5-(thiophen-2-yl)-pyrazoles; prenyl-protein transferase inhibitors | PHARMACEUTICAL PRODUCT DEVELOPMENT, LLC | 2007-06-28 | — | — | US | disclosed |
| US-7166619-B2 | Prenylation inhibitors and methods of their synthesis and use | PPD DISCOVERY , INC. (US) | 2007-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149549-A1 | 3-(Pyrid-3-yl)-5-(thiophen-2-yl)-pyrazoles; prenyl-protein transferase inhibitors | FNTA, PTAR1, ZMPSTE24 | ALDH1A1 3452/4885PLOD2 3370/4885CYP3A4 727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.