⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7840021 | 0.86 | NFE2L2 (0.36) | — | |
| SCHEMBL13929174 | 0.84 | — | — | |
| SCHEMBL7839894 | 0.84 | HPGD (0.35) | — | |
| SCHEMBL279289 | 0.78 | MAPT (0.33) | — | |
| SCHEMBL8041967 | 0.77 | GRIN2D (0.45) | — | |
| SCHEMBL13049933 | 0.77 | HPGD (0.44) | — | |
| SCHEMBL278954 | 0.77 | DRD2 (0.31) | — | |
| SCHEMBL13092326 | 0.77 | ALDH1A1 (0.30) | — | |
| SCHEMBL278919 | 0.76 | LMNA (0.40) | — | |
| SCHEMBL8043325 | 0.75 | PLA2G7 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7495007-B2 | Spiroindolinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-02-24 | — | — | US | disclosed |
| US-7495007-B2 | Spiroindolinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-02-24 | — | — | US | disclosed |
| US-20080009486-A1 | SPIROINDOLINONE DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2008-01-10 | — | — | US | disclosed |
| US-20080009486-A1 | SPIROINDOLINONE DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2008-01-10 | — | — | US | disclosed |