Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 | P47869 | 2/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.47 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2617373 | 0.89 | HTT (0.51) | GABRA2GABRB2TARBP2SMN1; SMN2NPC1 | |
| SCHEMBL10269164 | 0.88 | GABRA2 (0.44) | GABRA2GABRB2TARBP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL10269165 | 0.84 | TARBP2 (0.50) | GABRA2GABRB2TARBP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL13637087 | 0.78 | HTT (0.48) | GABRA2GABRB2TARBP2SMN1; SMN2NPC1 | |
| SCHEMBL13932504 | 0.78 | CASP3 (0.39) | GABRA2GABRB2TARBP2TLR8MAPT | |
| SCHEMBL2630582 | 0.77 | CENPE (0.36) | ALDH1A1NPC1RAB9AL3MBTL1TLR8 | |
| SCHEMBL14516368 | 0.76 | GABRA2 (0.41) | GABRA2GABRB2SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL14531655 | 0.75 | RAB9A (0.45) | GABRA2GABRB2TARBP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL23214261 | 0.75 | LMNA (0.42) | GABRA2GABRB2SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL31332945 | 0.75 | NPC1 (0.42) | GABRA2GABRB2SMN1; SMN2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504413-B2 | N-(4-(imidazo[1,2A]pyridin-YL)phenethyl)benzamide inhibitors of the mitotic kinesin CENP-E for treating certain cellular proliferation diseases | CYTOKINETICS, INC. (US) | 2009-03-17 | — | — | US | disclosed |