Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 8/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13938196 | 0.92 | FKBP1A (0.49) | FKBP1AF2PRSS1CTSLCTSK | |
| SCHEMBL1986802 | 0.89 | FKBP1A (0.48) | FKBP1AF2PRSS1CTSLCTSK | |
| SCHEMBL13938199 | 0.88 | KDM4E (0.50) | KDM4EKMT2AUSP30 | |
| SCHEMBL1979768 | 0.88 | FKBP1A (0.52) | FKBP1AF2PRSS1CTSLCTSK | |
| SCHEMBL1979169 | 0.88 | FKBP1A (0.55) | FKBP1AF2PRSS1CTSLCTSK | |
| SCHEMBL1979225 | 0.88 | USP30 (0.50) | KDM4EKMT2AUSP30 | |
| SCHEMBL1980404 | 0.84 | HSD17B10 (0.53) | FKBP1AF2PRSS1KMT2APIN1 | |
| SCHEMBL1979688 | 0.80 | STS (0.60) | KDM4EKMT2A | |
| SCHEMBL7207593 | 0.79 | FKBP1A (0.48) | FKBP1AF2CTSLCTSKCTRB1 | |
| SCHEMBL13938176 | 0.79 | STS (0.56) | KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7476680-B2 | Substituted heterocyclic compounds for treating multidrug resistance | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC. (US) | 2009-01-13 | — | — | US | disclosed |
| US-7476680-B2 | Substituted heterocyclic compounds for treating multidrug resistance | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC. (US) | 2009-01-13 | — | — | US | disclosed |