Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.44 |
| ▸ | TTK | P33981 | 4/20 | 0.37 |
| ▸ | MAPKAPK5 | Q8IW41 | 7/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13954838 | 0.89 | AURKA (0.45) | AURKAAURKBTTKMAPKAPK5PTK6 | |
| SCHEMBL14530182 | 0.80 | AURKA (0.53) | AURKAAURKBTTKMAPKAPK5 | |
| SCHEMBL14536959 | 0.80 | TTK (0.54) | AURKAAURKBTTKMAPKAPK5 | |
| SCHEMBL14537007 | 0.78 | AURKA (0.48) | AURKAAURKBTTKMAPKAPK5 | |
| SCHEMBL8241212 | 0.77 | AURKA (0.61) | AURKAAURKBTTKMAPKAPK5PTK6 | |
| SCHEMBL14537040 | 0.77 | AURKA (0.48) | AURKAAURKBTTKMAPKAPK5PTK6 | |
| SCHEMBL14537008 | 0.77 | AURKA (0.46) | AURKAAURKBTTK | |
| SCHEMBL14536794 | 0.77 | AURKA (0.48) | AURKAAURKBTTKMAPKAPK5 | |
| SCHEMBL14529898 | 0.76 | TTK (0.44) | AURKAAURKBTTKMAPKAPK5PTK6 | |
| SCHEMBL14530020 | 0.75 | AURKA (0.62) | AURKAAURKBTTKMAPKAPK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017701-A2 | ANTI-MITOTIC AGENT AND AURORA KINASE INHIBITOR COMBINATION AS ANTI-CANCER TREATMENT | SCHERING CORPORATION (US) | 2009-02-05 | — | — | WO | disclosed |