Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | TTK | P33981 | 1/20 | 0.43 |
| ▸ | MAPKAPK5 | Q8IW41 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14530182 | 0.85 | AURKA (0.53) | AURKAAURKBTTKMAPKAPK5 | |
| SCHEMBL14536959 | 0.85 | TTK (0.54) | AURKAAURKBTTKMAPKAPK5 | |
| SCHEMBL14537007 | 0.80 | AURKA (0.48) | AURKAAURKBTTKMAPKAPK5CDK2 | |
| SCHEMBL8239765 | 0.79 | AURKA (0.80) | AURKAAURKBTTKMAPKAPK5CDK2 | |
| SCHEMBL14537040 | 0.79 | AURKA (0.48) | AURKAAURKBTTKMAPKAPK5MAPT | |
| SCHEMBL14536833 | 0.79 | AURKA (0.48) | AURKAAURKBTTKMAPKAPK5 | |
| SCHEMBL14536795 | 0.78 | MAPKAPK5 (0.54) | AURKAAURKBMAPKAPK5 | |
| SCHEMBL1674354 | 0.77 | AURKA (0.65) | AURKAAURKBCA12CA1CA2 | |
| SCHEMBL14537008 | 0.77 | AURKA (0.46) | AURKAAURKBTTK | |
| SCHEMBL13157424 | 0.77 | AURKA (0.76) | AURKAAURKBTTKMAPKAPK5CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058873-A2 | IMIDAZOPYRAZINES AS CYCLIN DEPENTEND KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |