Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 3/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 6/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1351804 | 0.86 | KDM4E (0.62) | KDM4EALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL23229951 | 0.83 | PRMT6 (0.59) | KDM4EALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL24061764 | 0.83 | CHRM2 (0.60) | KDM4EALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL13948896 | 0.81 | ALDH1A1 (0.70) | KDM4EALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL13948897 | 0.81 | MMP13 (0.56) | KDM4EALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL13948894 | 0.81 | MRGPRX4 (0.52) | KDM4EMEN1KMT2APRMT6MAPT | |
| SCHEMBL16270473 | 0.81 | NOS1 (0.50) | KDM4ECHRM2CHRM1CHRM3NOS1 | |
| SCHEMBL13948890 | 0.80 | ALDH1A1 (0.55) | KDM4EALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL11090830 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL29370584 | 0.78 | CHRM2 (0.68) | KDM4EALDH1A1HTTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090030021-A1 | Quinazoline Derivatives and Therapeutic Use Thereof | REXAHN PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | US | disclosed |
| US-7388014-B2 | Quinazoline derivatives and therapeutic use thereof | REXAHN PHARMACEUTICALS, INC. (US) | 2008-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030021-A1 | Quinazoline Derivatives and Therapeutic Use Thereof | ABL1, NQO2, NRAS | KDM4E 4060/4885ALDH1A1 2085/4885HTT 2904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.