Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GNAI3 | P08754 | 5/20 | 0.46 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.46 |
| ▸ | GNAO1 | P09471 | 4/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | CHKA | P35790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23813810 | 0.88 | CA2 (0.43) | ATMNPC1GNAI3GNAI1GNAO1 | |
| SCHEMBL10337915 | 0.84 | GNAI3 (0.56) | ATMNPC1GNAI3GNAI1GNAO1 | |
| SCHEMBL16756662 | 0.84 | GNAI3 (0.56) | ATMNPC1GNAI3GNAI1GNAO1 | |
| SCHEMBL9415827 | 0.84 | GNAI3 (0.56) | ATMNPC1GNAI3GNAI1GNAO1 | |
| SCHEMBL9415769 | 0.84 | GNAI3 (0.56) | ATMNPC1GNAI3GNAI1GNAO1 | |
| SCHEMBL2998705 | 0.82 | L3MBTL1 (0.60) | ATMNPC1GNAI3GNAI1GNAO1 | |
| SCHEMBL29649523 | 0.82 | ITGB3 (0.64) | ATMNPC1GNAI3GNAI1GNAO1 | |
| SCHEMBL25867742 | 0.82 | ATM (0.78) | ATMNPC1L3MBTL1MEN1KMT2A | |
| SCHEMBL1073791 | 0.81 | L3MBTL1 (0.69) | ATMNPC1GNAI3GNAI1GNAO1 | |
| SCHEMBL6043280 | 0.80 | ATM (0.50) | ATMNPC1GNAI3GNAI1GNAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210228615-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2021-07-29 | — | — | US | disclosed |
| US-20200157545-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2020-05-21 | — | — | US | disclosed |
| WO-2019075357-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2019-04-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210228615-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF | SMN1; SMN2, RBM17, RBM22 | ATM 2102/4885NPC1 4454/4885GNAI3 2130/4885 |
| US-20200157545-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF | RNASE1, RNASEH1, RNASEL | ATM 4293/4885NPC1 1153/4885GNAI3 1256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.