Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 12/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | MMP8 | P22894 | 1/20 | 0.52 |
| ▸ | MMP14 | P50281 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13986969 | 0.89 | GAA (0.57) | SNCAHPGDPTGS1PTGS2MAPT | |
| SCHEMBL13986973 | 0.88 | SIRT1 (0.56) | PTGS1PTGS2GSK3B | |
| SCHEMBL14374752 | 0.88 | SNCA (0.49) | SNCAHPGDPTGS1PTGS2MAPT | |
| SCHEMBL13987008 | 0.87 | KMT2A (0.59) | HPGDPTGS1PTGS2MTNR1AMTNR1B | |
| SCHEMBL4851138 | 0.86 | GSK3B (0.58) | MAPTGSK3B | |
| SCHEMBL13986979 | 0.81 | MAPT (0.65) | MAPTGSK3B | |
| SCHEMBL13986972 | 0.81 | MTNR1A (0.56) | HPGDPTGS1PTGS2MAPTMTNR1A | |
| SCHEMBL13986976 | 0.81 | P2RX7 (0.63) | HPGDMAPTGSK3B | |
| SCHEMBL9936292 | 0.81 | SNCA (0.81) | SNCAHPGDMAPT | |
| SCHEMBL9936203 | 0.78 | HPGD (0.73) | SNCAHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |