Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CDK4 | P11802 | 5/20 | 0.54 |
| ▸ | CCND1 | P24385 | 5/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13986969 | 0.88 | GAA (0.57) | SMN1; SMN2PTGS1PTGS2NPC1RAB9A | |
| SCHEMBL13986980 | 0.88 | SNCA (0.60) | PTGS1PTGS2GSK3B | |
| SCHEMBL14374752 | 0.86 | SNCA (0.49) | SIRT1SMN1; SMN2PTGS1PTGS2GSK3B | |
| SCHEMBL13986972 | 0.86 | MTNR1A (0.56) | MEN1KMT2APTGS1PTGS2NPC1 | |
| SCHEMBL13987008 | 0.86 | KMT2A (0.59) | MEN1KMT2APTGS1PTGS2RAB9A | |
| SCHEMBL13986976 | 0.83 | P2RX7 (0.63) | MEN1KMT2APOLBGSK3B | |
| SCHEMBL13987007 | 0.82 | GSK3B (0.46) | SIRT1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL13986957 | 0.82 | GSK3B (0.56) | KMT2APOLBGSK3B | |
| SCHEMBL13986983 | 0.82 | GSK3B (0.64) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL13986958 | 0.80 | LMNA (0.62) | MEN1KMT2ASMN1; SMN2POLBGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |