Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ICMT | O60725 | 1/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8983732 | 0.86 | CYP1A2 (0.44) | CYP1A2HSD17B10GAAMAPTTSHR | |
| Benzene SCHEMBL27474313 | 0.84 | CYP1A2 (0.61) | CYP1A2HSD17B10GAAMAPTTSHR | |
| SCHEMBL6248402 | 0.84 | CYP1A2 (0.61) | CYP1A2HSD17B10GAAMAPTTSHR | |
| SCHEMBL11756536 | 0.83 | CYP1A2 (0.42) | CYP1A2HSD17B10MAPTTSHRALDH1A1 | |
| SCHEMBL13784467 | 0.83 | POLB (0.46) | CYP1A2HSD17B10GAAMAPTTSHR | |
| SCHEMBL8667770 | 0.81 | LMNA (0.48) | SIRT1KDM4ECYP1A2HSD17B10GAA | |
| SCHEMBL7584830 | 0.80 | RAB9A (0.47) | CYP1A2HSD17B10GAAMAPTTSHR | |
| SCHEMBL11784378 | 0.79 | CYP1A2 (0.40) | KDM4ECYP1A2HSD17B10GAANPSR1 | |
| Phenylhydrazine SCHEMBL11784450 | 0.77 | CYP1A2 (0.49) | KDM4ECYP1A2HSD17B10GAAMAPT | |
| SCHEMBL6780943 | 0.77 | PTGS2 (0.53) | SIRT1KDM4ECYP1A2HSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1086693-C | Method for producing alkylsulfinylbenzamides and 1,2-benzisothiazol-3-ones | SUMITOMO SEIKA CHEMICAL CO LTD (JP) | 2002-06-26 | — | — | CN | claimed |
| CN-1215721-A | Method for producing alkylsulfinylbenzamides and 1,2-benzisothiazol-3-ones | SUMITOMO SEIKA CHEMICALS (JP) | 1999-05-05 | — | — | CN | claimed |
| CN-1215722-A | Method for producing alkylsulfinylbenzamides and 1,2-benzisothiazol-3-ones | SUMITOMO SEIKA CHEMICALS (JP) | 1999-05-05 | — | — | CN | claimed |
| CN-1042530-C | Process for producing alkylsulfinylbenzamides | SUMITOMO SEIKA CHEMICALS (JP) | 1999-03-17 | — | — | CN | claimed |
| US-5744609-A | REACTING AN ALKYLTHIOBENZAMIDE WITH A HALOGEN IN A HETEROGENOUS SOLVENT TO GIVE ALKYLSULFURYLBENZAMIDES INTERMEDIATES; USEFUL ANTIBACTERIAL AND ANTIFUNGAL AGENT | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 1998-04-28 | — | — | US | claimed |
| EP-0657438-B1 | Method for producing 1,2-benzisothiazol-3-ones | SUMITOMO SEIKA CHEMICALS (JP) | 1997-07-30 | — | — | EP | claimed |
| US-5508416-A | HALOGENATING A 2-(ALKYLTHIO)BENZAMIDE, CYCLIZATION TO HETERO RING AND N-S LINKAGE | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 1996-04-16 | — | — | US | claimed |
| CN-1107837-A | Process for producing alkylsulfinylbenzamides and 1, 2-benzisothiazol-3-ones | SUMITOMO SEIKA CHEMICALS (JP) | 1995-09-06 | — | — | CN | claimed |
| EP-0657438-A2 | Method for producing alkylsulfinylbenzamides and 1,2-benzisothiazol-3-ones | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 1995-06-14 | — | — | EP | claimed |
| JP-7196638-A | — | — | None | — | — | JP | disclosed |
| JP-7330745-A | — | — | None | — | — | JP | disclosed |
| EP-1860100-B1 | 2-(1H-indolylsulfanyl)-benzyl amine derivatives as SSRI | LUNDBECK & CO AS H (DK) | 2011-03-02 | — | — | EP | disclosed |
| US-7737170-B2 | Uses of 2-(1H-indolylsulfanyl)-benzyl amine derivatives as SSRIS | H. LUNDBECK A/S (DK) | 2010-06-15 | — | — | US | disclosed |
| US-7737171-B2 | Uses of 2-(1H-indolylsulfanyl)-benzyl amine derivatives as SSRIS | H. LUNDBECK A/S (DK) | 2010-06-15 | — | — | US | disclosed |
| JP-H07196638-A | PRODUCTION OF 1,2-BENZISOTHIAZOL-3-ONES | SUMITOMO SEIKA CHEM CO LTD | 1995-08-01 | — | — | JP | disclosed |
| EP-0657438-A2 | Method for producing alkylsulfinylbenzamides and 1,2-benzisothiazol-3-ones | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 1995-06-14 | — | — | EP | disclosed |
| EP-0657438-A2 | Method for producing alkylsulfinylbenzamides and 1,2-benzisothiazol-3-ones | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 1995-06-14 | — | — | EP | disclosed |
| EP-0067615-B1 | ALKYLTHIO DERIVATIVES OF AZABICYCLOBENZAMIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | BEECHAM GROUP PLC (GB) | 1986-01-08 | — | — | EP | disclosed |
| US-4499099-A | NERVOUS SYSTEM, PSYCHOLOGICAL DISORDERS | BEECHAM GROUP P.L.C. (GB) | 1985-02-12 | — | — | US | disclosed |
| EP-0067615-A1 | Alkylthio derivatives of azabicyclobenzamides, their preparation and pharmaceutical compositions | BEECHAM GROUP PLC (GB) | 1982-12-22 | — | — | EP | disclosed |