Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.34 |
| ▸ | AKT1 | P31749 | 7/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | AKT2 | P31751 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14005375 | 0.91 | L3MBTL1 (0.37) | HTTAKT1ROCK2PIM1RPS6KB1 | |
| SCHEMBL14030047 | 0.87 | OPRM1 (0.38) | HTTOPRM1AKT1ROCK2PIM1 | |
| SCHEMBL14068598 | 0.86 | OPRM1 (0.36) | HTTOPRM1AKT1ROCK2PIM1 | |
| SCHEMBL14005378 | 0.84 | AKT1 (0.37) | AKT1ROCK2PIM1RPS6KB1AKT2 | |
| SCHEMBL14005376 | 0.83 | CHRM2 (0.37) | HTTAKT1ROCK2PIM1RPS6KB1 | |
| SCHEMBL14030197 | 0.78 | ALDH1A1 (0.39) | HTTAKT1ROCK2PIM1RPS6KB1 | |
| SCHEMBL14005330 | 0.75 | CASR (0.47) | AKT1ROCK2PIM1RPS6KB1AKT2 | |
| SCHEMBL4893022 | 0.74 | PDPK1 (0.66) | AKT1RPS6KB1 | |
| SCHEMBL14005389 | 0.72 | AKT1 (0.35) | AKT1ROCK2RPS6KB1AKT2RPS6KA3 | |
| SCHEMBL14004831 | 0.72 | AKT1 (0.48) | AKT1ROCK2PIM1RPS6KB1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | WYETH (US) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | PDPK1, PDK2, PDK3 | HTT 2725/4885OPRM1 3858/4885AKT1 157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.