Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | MET | P08581 | 8/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | SGK1 | O00141 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14007177 | 0.91 | NOS1 (0.38) | MAP4K4NOS1MAPK14METKDM4E | |
| SCHEMBL14007182 | 0.84 | MAP4K4 (0.39) | MAP4K4NOS1MAPK14METJAK2 | |
| SCHEMBL14007180 | 0.76 | MAPK14 (0.39) | NOS1MAPK14METMAPK1MAPK13 | |
| SCHEMBL14565329 | 0.75 | MAP4K4 (0.36) | MAP4K4 | |
| SCHEMBL4922720 | 0.75 | NOS1 (0.38) | NOS1MAPK14METMAPK1SGK1 | |
| SCHEMBL14086453 | 0.70 | MAP4K4 (0.35) | MAP4K4MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4918755 | 0.70 | NOS1 (0.46) | NOS1METALDH1A1MAPK1SGK1 | |
| SCHEMBL13906949 | 0.70 | MAPK14 (0.33) | MAP4K4MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL14007181 | 0.69 | MET (0.35) | NOS1MAPK14METNPC1RAB9A | |
| SCHEMBL4927478 | 0.69 | NOS1 (0.44) | NOS1METMAPK1SGK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080280766-A1 | Pyridopyrazines for Combating Phytopathogenic Fungi | SYNGENTA CROP PROTECTION, INC. (US) | 2008-11-13 | — | — | US | disclosed |
| US-20080280766-A1 | Pyridopyrazines for Combating Phytopathogenic Fungi | SYNGENTA CROP PROTECTION, INC. (US) | 2008-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280766-A1 | Pyridopyrazines for Combating Phytopathogenic Fungi | Q6ZSR9, GRHPR, PRXL2A | MAP4K4 2379/4885NOS1 1227/4885MAPK14 2837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.