SCHEMBL1401027

SCHEMBL1401027

CCOC(=O)CCCN([C]=O)[Si](C)(C)C

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.46
RAB9A P51151 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
TSHR P16473 2/20 0.41
LMNA P02545 1/20 0.41
POLB P06746 1/20 0.41
ALOX5 P09917 1/20 0.40
ALDH1A1 P00352 4/20 0.40
NR1I2 O75469 1/20 0.38
PGR P06401 1/20 0.38
ADORA3 P0DMS8 1/20 0.38
PTGS2 P35354 1/20 0.38
PDE4D Q08499 1/20 0.38
DRD2 P14416 1/20 0.37
ALOX15 P16050 2/20 0.36
TDP1 Q9NUW8 2/20 0.36
MGAM O43451 1/20 0.36
GAA P10253 1/20 0.36
SI P14410 1/20 0.36
MGAM2 Q2M2H8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1401008 0.85 CYP1A2 (0.44) CYP1A2RAB9AL3MBTL1TSHRLMNA
SCHEMBL1401057 0.84 CYP1A2 (0.41) CYP1A2RAB9AL3MBTL1TSHRLMNA
SCHEMBL7282328 0.83 CYP1A2 (0.40) CYP1A2RAB9AL3MBTL1TSHRLMNA
SCHEMBL1401271 0.83 DNM1 (0.46) L3MBTL1TSHRLMNAALDH1A1USP2
SCHEMBL1477937 0.77 CYP1A2 (0.50) CYP1A2RAB9AL3MBTL1TSHRLMNA
SCHEMBL31325279 0.74 CYP1A2 (0.59) CYP1A2RAB9ATSHRALOX5ALDH1A1
SCHEMBL31357582 0.74 CYP1A2 (0.59) CYP1A2RAB9ATSHRALOX5ALDH1A1
SCHEMBL1481090 0.74 CYP1A2 (0.50) CYP1A2RAB9AL3MBTL1TSHRALOX5
SCHEMBL9235430 0.73 CYP1A2 (0.46) CYP1A2RAB9AL3MBTL1TSHRPOLB
SCHEMBL4618714 0.72 CYP1A2 (0.57) CYP1A2RAB9AL3MBTL1TSHRPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 169 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230103337-A1 MEDICINE FOR IMPROVING STATE OF PREGNANCY, AND USE THEREOF Yamaguchi, Koushi (JP) 2023-04-06 US disclosed
US-11541040-B2 Medicine for improving state of pregnancy, and use thereof Yamaguchi, Kouchi (JP) 2023-01-03 US disclosed
EP-3977995-A1 TACROLIMUS FOR AMELIORATING PREGNANCY CONDITIONS Yamaguchi, Koushi (JP) 2022-04-06 EP disclosed
EP-3900729-A1 AGENT FOR IMPROVING INFERTILITY, RECURRENT MISCARRIAGE, AND STATE OF PREGNANCY Yamaguchi, Koushi (JP) 2021-10-27 EP disclosed
EP-3246036-B1 MEDICINE FOR IMPROVING PREGNANCY-INDUCED HYPERTENSION SYNDROME YAMAGUCHI KOUSHI (JP) 2021-10-13 EP disclosed
US-20210228551-A1 THERAPEUTIC AGENT FOR HUMORAL IMMUNITY-RELATED DISEASES IN MATERNOFETAL RELATIONSHIP YAMAGUCHI KOUSHI (JP) 2021-07-29 US disclosed
EP-3834826-A1 THERAPEUTIC AGENT FOR HUMORAL IMMUNITY-RELATED DISEASES IN MATERNO-FETAL RELATIONSHIP Yamaguchi, Koushi (JP) 2021-06-16 EP disclosed
WO-2020129348-A1 AGENT FOR IMPROVING INFERTILITY, RECURRENT MISCARRIAGE, AND STATE OF PREGNANCY 山口 晃史 2020-06-25 WO disclosed
WO-2020032252-A1 THERAPEUTIC AGENT FOR HUMORAL IMMUNITY-RELATED DISEASES IN MATERNO-FETAL RELATIONSHIP 山口 晃史 2020-02-13 WO disclosed
US-20190099406-A1 MEDICINE FOR IMPROVING STATE OF PREGNANCY, AND USE THEREOF Yamaguchi, Koushi (JP) 2019-04-04 US disclosed
US-5215995-A For treatment of baldness or alopecia FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-06-01 US disclosed
EP-0536401-A1 TRICYCLO COMPOUNDS, A PROCESS FOR THEIR PRODUCTION AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-04-14 EP disclosed
US-5196437-A Macrolide FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) 1993-03-23 US disclosed
WO-1992013862-A1 LACTONE COMPOUNDS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-08-20 WO disclosed
EP-0484936-A1 Suspensions containing tricyclic compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-05-13 EP disclosed
EP-0483842-A1 Pharmaceutical compositions containing tricyclic compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-05-06 EP disclosed
US-5110811-A Antibody inhibitors FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) 1992-05-05 US disclosed
WO-1992000313-A1 TRICYCLO COMPOUNDS, A PROCESS FOR THEIR PRODUCTION AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-01-09 WO disclosed
WO-1991017754-A1 METHODS FOR TREATING AND PREVENTING INFLAMMATION OF MUCOSA AND BLOOD VESSELS USING FK 506 AND RELATED COMPOUNDS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1991-11-28 WO disclosed
US-4929611-A ANTIBODY INHIBITORS FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) 1990-05-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230103337-A1 MEDICINE FOR IMPROVING STATE OF PREGNANCY, AND USE THEREOF PGF, SLC10A1, SLC26A4 CYP1A2 295/4885RAB9A 2467/4885L3MBTL1 4469/4885
US-20190099406-A1 MEDICINE FOR IMPROVING STATE OF PREGNANCY, AND USE THEREOF PGF, SLC10A1, SLC26A4 CYP1A2 304/4885RAB9A 2360/4885L3MBTL1 4415/4885
US-11541040-B2 Medicine for improving state of pregnancy, and use thereof PGF, SLC10A1, SLC26A4 CYP1A2 304/4885RAB9A 2360/4885L3MBTL1 4415/4885
US-20210228551-A1 THERAPEUTIC AGENT FOR HUMORAL IMMUNITY-RELATED DISEASES IN MATERNOFETAL RELATIONSHIP PGF, HAMP, HLA-DRB1 CYP1A2 3359/4885RAB9A 987/4885L3MBTL1 1005/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.