Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 5/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.43 |
| ▸ | CPT2 | P23786 | 1/20 | 0.42 |
| ▸ | CPT1A | P50416 | 1/20 | 0.42 |
| ▸ | CAMKK2 | Q96RR4 | 4/20 | 0.42 |
| ▸ | CAMKK1 | Q8N5S9 | 3/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4708703 | 0.90 | PTGS2 (0.45) | KEAP1NFE2L2CAMKK2CAMKK1KDR | |
| SCHEMBL14014888 | 0.86 | CAMKK2 (0.47) | KEAP1NFE2L2CAMKK2CAMKK1FLT3 | |
| SCHEMBL4708491 | 0.85 | HSD17B10 (0.47) | KEAP1NFE2L2CAMKK2CAMKK1PIM1 | |
| SCHEMBL14014911 | 0.85 | CAMKK1 (0.44) | KEAP1NFE2L2CAMKK2CAMKK1KDR | |
| SCHEMBL14014880 | 0.84 | KEAP1 (0.46) | KEAP1NFE2L2CAMKK2CAMKK1FLT3 | |
| SCHEMBL14014913 | 0.83 | KDM4E (0.46) | KEAP1NFE2L2CAMKK2CAMKK1NTRK1 | |
| SCHEMBL14014894 | 0.82 | ACVR1 (0.40) | CAMKK2NTRK1METPIM1FGFR1 | |
| SCHEMBL14014496 | 0.80 | KDM4E (0.56) | KEAP1NFE2L2CAMKK2CAMKK1FLT3 | |
| SCHEMBL4710750 | 0.79 | KDM4E (0.52) | KEAP1NFE2L2CAMKK2CAMKK1FLT3 | |
| SCHEMBL6211737 | 0.79 | CAMKK2 (0.40) | KEAP1NFE2L2CAMKK2CAMKK1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |