Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.45 |
| ▸ | LOX | P28300 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.43 |
| ▸ | HBB | P68871 | 1/20 | 0.43 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16792635 | 0.86 | UHRF1 (0.46) | LOXL2LOXSMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL18181863 | 0.84 | ALDH1A1 (0.47) | LOXL2LOXSMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL22530482 | 0.78 | MAPT (0.45) | LOXL2SMN1; SMN2CYP1A2CYP2C19NPC1 | |
| SCHEMBL29351922 | 0.78 | MAPT (0.45) | LOXL2SMN1; SMN2CYP1A2CYP2C19NPC1 | |
| SCHEMBL22117010 | 0.77 | GABRG2 (0.48) | LOXL2SMN1; SMN2RAB9AALDH1A1NUDT1 | |
| SCHEMBL29693800 | 0.76 | ALDH1A1 (0.44) | LOXL2LOXSMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL16792623 | 0.76 | SMN1; SMN2 (0.46) | LOXL2LOXSMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL16792742 | 0.76 | LOXL2 (0.42) | LOXL2LOXSMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL30294911 | 0.74 | NNMT (0.50) | LOXL2LOXALDH1A1KDM4EMEN1 | |
| SCHEMBL15939077 | 0.74 | NNMT (0.50) | LOXL2LOXALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7452880-B2 | Substituted pyrazolo [3,4-d] pyrimidines and methods of using the same | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-18 | — | — | US | disclosed |