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SCHEMBL1401853

SCHEMBL1401853

C=COC(=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)OC(C)=O

nearest known ligand 0.63

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 1/20 0.63
▸ POLB P06746 1/20 0.42
▸ MAPK1 P28482 1/20 0.42
▸ ABCB1 P08183 1/20 0.40
▸ NPY1R P25929 1/20 0.33
▸ USP2 O75604 2/20 0.32
▸ CYP3A4 P08684 2/20 0.32
▸ MAPT P10636 2/20 0.32
▸ SMN1; SMN2 Q16637 2/20 0.32
▸ LMNA P02545 1/20 0.32
▸ RECQL P46063 1/20 0.32
▸ PGD P52209 1/20 0.32
▸ ALDH1A1 P00352 1/20 0.31
▸ HPGD P15428 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7152392 0.81 TDP1 (0.71) TDP1POLBMAPK1ABCB1NPY1R
SCHEMBL7146573 0.81 TDP1 (0.71) TDP1POLBMAPK1ABCB1NPY1R
SCHEMBL7151458 0.81 TDP1 (0.71) TDP1POLBMAPK1ABCB1NPY1R
SCHEMBL7152328 0.81 TDP1 (0.71) TDP1POLBMAPK1ABCB1NPY1R
SCHEMBL15267778 0.81 TDP1 (0.76) TDP1POLBMAPK1ABCB1NPY1R
SCHEMBL826717 0.80 TDP1 (0.96) TDP1POLBMAPK1ABCB1MAPT
SCHEMBL2175855 0.80 TDP1 (0.96) TDP1POLBMAPK1ABCB1MAPT
SCHEMBL270042 0.80 TDP1 (0.96) TDP1POLBMAPK1ABCB1MAPT
SCHEMBL7149374 0.80 TDP1 (0.96) TDP1POLBMAPK1ABCB1MAPT
SCHEMBL7150717 0.80 TDP1 (0.96) TDP1POLBMAPK1ABCB1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11008414-B2 Polymer materials for contact lens applications CIS PHARMA AG (CH) 2021-05-18 — — US disclosed
US-20200283560-A1 New polymer materials for contact lens applications CIS PHARMA AG (CH) 2020-09-10 — — US disclosed
EP-3356433-B1 NEW POLYMER MATERIALS FOR CONTACT LENS APPLICATIONS CIS PHARMA AG (CH) 2019-09-18 — — EP disclosed
US-20180346629-A1 Biocompatible polymers and co-polymers, and uses thereof GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE 2018-12-06 — — US disclosed
EP-3356433-A1 NEW POLYMER MATERIALS FOR CONTACT LENS APPLICATIONS CIS Pharma AG (CH) 2018-08-08 — — EP disclosed
EP-2292672-B1 Biocompatible polymers and co-polymers comprising amino acids in the side chain CIS PHARMA AG (CH) 2018-05-09 — — EP disclosed
US-9839719-B2 Biocompatible polymers and co-polymers, and uses thereof CIS PHARMA AG (CH) 2017-12-12 — — US disclosed
US-20170152335-A1 Biocompatible polymers and co-polymers, and uses thereof HITZ HANS (CH) 2017-06-01 — — US disclosed
EP-1888660-B1 BIOCOMPATIBLE POLYMERS AND CO-POLYMERS COMPRISING AMINO ACIDS IN THE SIDE CHAIN CIS PHARMA AG (CH) 2017-05-17 — — EP disclosed
EP-2523982-B1 METHODS FOR THE PREPARATION OF BIOCOMPATIBLE POLYMERS, THE POLYMERS AND THEIR USES CIS PHARMA AG (CH) 2015-04-29 — — EP disclosed
EP-0212959-B1 SUSTAINED-RELEASE FORMULATION CONTAINING AN AMIN ACID POLYMER WITH A LOWER ALKYL (C1-C4) POLAR SOLVENT BAUSCH & LOMB INCORPORATED (US) 1993-03-03 — — EP disclosed
EP-0219207-B1 SUSTAINED-RELEASE FORMULATION COMPRISING A HYDROPHOBIC POLYMER SYSTEM BAUSCH & LOMB INCORPORATED (US) 1992-07-01 — — EP disclosed
EP-0219208-B1 SUBSTAINED-RELEASE FORMULATION CONTAINING AN AMINO ACID POLYMER BAUSCH & LOMB INCORPORATED (US) 1992-06-24 — — EP disclosed
US-4931279-A Sustained release formulation containing an ion-exchange resin BAUSCH & LOMB INCORPORATED (US) 1990-06-05 — — US disclosed
US-4713244-A Sustained-release formulation containing an amino acid polymer with a lower alkyl (C1 -C4) polar solvent BAUSCH & LOMB INCORPORATED (US) 1987-12-15 — — US disclosed
US-4668506-A Sustained-release formulation containing and amino acid polymer BAUSCH & LOMB INCORPORATED (US) 1987-05-26 — — US disclosed
US-4663409-A Alpha, beta-unsaturated carbonyl modified amino acid monomer and polymers for biomedical uses BAUSCH & LOMB INCORPORATED (US) 1987-05-05 — — US disclosed
EP-0219207-A2 Sustained-release formulation comprising a hydrophobic polymer system BAUSCH & LOMB INCORPORATED (US) 1987-04-22 — — EP disclosed
EP-0219208-A2 Substained-release formulation containing an amino acid polymer BAUSCH & LOMB INCORPORATED (US) 1987-04-22 — — EP disclosed
EP-0212959-A2 Sustained-release formulation containing an amin acid polymer with a lower alkyl (C1-C4) polar solvent BAUSCH & LOMB INCORPORATED (US) 1987-03-04 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170152335-A1 Biocompatible polymers and co-polymers, and uses thereof ARG1, CRYAA, COL1A1 TDP1 3259/4885POLB 3330/4885MAPK1 93/4885
US-20200283560-A1 New polymer materials for contact lens applications CRYAA, CRYAB, BCAT1 TDP1 4067/4885POLB 3215/4885MAPK1 567/4885
US-11008414-B2 Polymer materials for contact lens applications CRYAA, BCAT1, CRYAB TDP1 3952/4885POLB 2963/4885MAPK1 848/4885
US-20180346629-A1 Biocompatible polymers and co-polymers, and uses thereof ARG1, CRYAA, COL1A1 TDP1 3259/4885POLB 3330/4885MAPK1 93/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.