Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 9/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.36 |
| ▸ | IGF1R | P08069 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 4/20 | 0.36 |
| ▸ | BRD1 | O95696 | 4/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 4/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13764828 | 0.78 | MAPK14 (0.42) | BRD4 | |
| SCHEMBL14019142 | 0.75 | BRPF1 (0.42) | BRD4CREBBPTRIM24BRD1BRPF1 | |
| SCHEMBL31613196 | 0.69 | CYP1A2 (0.42) | BRD4CREBBP | |
| SCHEMBL30896348 | 0.68 | HTR6 (0.48) | — | |
| SCHEMBL7708458 | 0.67 | RECQL (0.51) | BRD4NTRK1IGF1RFGFR1NTRK2 | |
| SCHEMBL15722441 | 0.66 | BRD4 (0.44) | BRD4CREBBP | |
| SCHEMBL30896342 | 0.65 | HAO1 (0.45) | — | |
| SCHEMBL28623299 | 0.65 | KDM4E (0.38) | BRD4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL19153933 | 0.65 | PDE3B (0.39) | — | |
| SCHEMBL5206240 | 0.63 | NOS1 (0.45) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435731-B2 | Substituted pyrazolo[3,4-d]pyrimadines and methods of using the same | ROCHE PALO ALTO LLC (US) | 2008-10-14 | — | — | US | disclosed |