Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 7/20 | 0.42 |
| ▸ | TRIM24 | O15164 | 6/20 | 0.42 |
| ▸ | BRD1 | O95696 | 6/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14019141 | 0.75 | BRD4 (0.39) | BRPF1TRIM24BRD1BRD4CREBBP | |
| SCHEMBL14019137 | 0.73 | BRD4 (0.45) | ALDH1A1BRD4LMNANPSR1MAOA | |
| SCHEMBL31613196 | 0.71 | CYP1A2 (0.42) | BRD4CREBBPCYP1A2MCHR1 | |
| SCHEMBL30896348 | 0.69 | HTR6 (0.48) | ALDH1A1MEN1LMNAPOLBKMT2A | |
| SCHEMBL15722441 | 0.68 | BRD4 (0.44) | ALDH1A1BRD4MEN1LMNAPOLB | |
| SCHEMBL14038745 | 0.68 | MAPK14 (0.58) | MAPK14HIF1AALDH1A1MEN1KMT2A | |
| SCHEMBL30896342 | 0.67 | HAO1 (0.45) | — | |
| SCHEMBL14014073 | 0.66 | MAPK14 (0.56) | MAPK14ALDH1A1MEN1POLBKMT2A | |
| SCHEMBL14019140 | 0.65 | MAOA (0.38) | MAPK14ALDH1A1BRD4POLBATM | |
| SCHEMBL19873777 | 0.65 | BRD4 (0.43) | BRD4POLBMAOAMAOBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435731-B2 | Substituted pyrazolo[3,4-d]pyrimadines and methods of using the same | ROCHE PALO ALTO LLC (US) | 2008-10-14 | — | — | US | disclosed |