Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14019138 | 0.76 | ALDH1A1 (0.40) | BRD4ALDH1A1HSD17B10USP2CYP1A2 | |
| SCHEMBL14019142 | 0.73 | BRPF1 (0.42) | BRD4ALDH1A1CYP1A2LMNAHTT | |
| SCHEMBL13923956 | 0.69 | NUDT14 (0.46) | BRD4ALDH1A1KDRLMNAL3MBTL1 | |
| SCHEMBL14019140 | 0.67 | MAOA (0.38) | BRD4ALDH1A1CYP1A2CYP2C9TP53 | |
| SCHEMBL8214146 | 0.65 | NUDT14 (0.50) | ALDH1A1LMNAL3MBTL1KDM4EGAA | |
| SCHEMBL14038745 | 0.64 | MAPK14 (0.58) | ALDH1A1HSD17B10USP2CYP1A2CYP3A4 | |
| SCHEMBL20135868 | 0.63 | BRD4 (0.74) | BRD4 | |
| SCHEMBL15717150 | 0.62 | BRD4 (0.62) | BRD4ALDH1A1HSD17B10CASP1CASP7 | |
| SCHEMBL11688645 | 0.62 | L3MBTL1 (0.55) | BRD4ALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL8224982 | 0.62 | HPGD (0.74) | ALDH1A1TP53LMNAL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435731-B2 | Substituted pyrazolo[3,4-d]pyrimadines and methods of using the same | ROCHE PALO ALTO LLC (US) | 2008-10-14 | — | — | US | disclosed |