Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.45 |
| ▸ | GSK3B | P49841 | 3/20 | 0.45 |
| ▸ | NFATC1 | O95644 | 3/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.40 |
| ▸ | KRAS | P01116 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14021918 | 0.88 | HTR6 (0.65) | HTR6GSK3BGPR84KRASHTR2A | |
| SCHEMBL14214431 | 0.85 | HTR6 (0.45) | HTR6DYRK1AGSK3BNFATC1GPR84 | |
| SCHEMBL18858475 | 0.82 | HTR6 (0.53) | HTR6DYRK1AGSK3BNFATC1GPR84 | |
| SCHEMBL25987660 | 0.80 | HTR6 (0.58) | HTR6DYRK1AGSK3BNFATC1GPR84 | |
| SCHEMBL3899319 | 0.79 | HTR6 (0.76) | HTR6DYRK1AGSK3BNFATC1HTR2A | |
| SCHEMBL3924792 | 0.79 | GSK3B (0.53) | HTR6DYRK1AGSK3BNFATC1GPR84 | |
| SCHEMBL31036068 | 0.79 | HTR6 (0.76) | HTR6DYRK1AGSK3BNFATC1HTR2A | |
| SCHEMBL17338514 | 0.79 | GPR84 (0.44) | HTR6DYRK1AGSK3BNFATC1GPR84 | |
| SCHEMBL3221770 | 0.78 | DYRK1A (0.51) | HTR6DYRK1AGSK3BNFATC1GPR84 | |
| SCHEMBL25029930 | 0.78 | HTR2A (0.62) | HTR6DYRK1AGSK3BNFATC1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080267942-A1 | BENZAZEPIN-2(1H)-ONE DERIVATIVES | PFIZER LIMITED (GB) | 2008-10-30 | — | — | US | disclosed |
| US-20080103130-A1 | 7-hydroxy-6-{[1-methyl-3-(1,3-thiazol-5-yl)propyl]amino}-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1]benzazepin-2(1H)-one; agonists at the beta-2 adrenoceptor; feed additives for livestock animals; improving meat yield or meat quality | PFIZER LIMITED (GB) | 2008-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080103130-A1 | 7-hydroxy-6-{[1-methyl-3-(1,3-thiazol-5-yl)propyl]amino}-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1]benzazepin-2(1H)-one; agonists at the beta-2 adrenoceptor; feed additives for livestock animals; improving meat yield or meat quality | ADRB2, ADRB1, ADRA2C | HTR6 243/4885DYRK1A 3040/4885GSK3B 2156/4885 |
| US-20080267942-A1 | BENZAZEPIN-2(1H)-ONE DERIVATIVES | ADRB2, ADRB1, ADRA2C | HTR6 992/4885DYRK1A 3924/4885GSK3B 2045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.