SCHEMBL14022342

SCHEMBL14022342

CN(C)C(=O)Nc1cc(C=O)ccn1

nearest known ligand 0.46

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
FGFR4 P22455 2/20 0.46
PIK3C3 Q8NEB9 5/20 0.40
KDM4E B2RXH2 1/20 0.38
ABL1 P00519 1/20 0.38
APEX1 P27695 1/20 0.37
GCK P35557 1/20 0.37
MAP4K1 Q92918 1/20 0.37
TSHR P16473 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7365972 0.82 L3MBTL1 (0.52) PIK3C3
SCHEMBL29951814 0.82 L3MBTL1 (0.52) PIK3C3
SCHEMBL2555419 0.80 EGFR (0.42) GCK
SCHEMBL12062550 0.79 NPC1 (0.54)
SCHEMBL22809551 0.78 TYK2 (0.50) KDM4EMAP4K1
SCHEMBL5777715 0.78 LMNA (0.47) KDM4EABL1
SCHEMBL18266478 0.78 JAK2 (0.50) KDM4E
SCHEMBL22408359 0.78 FGFR4 (0.57) FGFR4PIK3C3APEX1TSHR
SCHEMBL22809622 0.76 RAB9A (0.45) TSHR
SCHEMBL22809499 0.75 ACVRL1 (0.58) PIK3C3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008119569-A1 SYNTHESIS OF ANTHRANILAMIDES BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-10-09 WO disclosed
US-20080242866-A1 SYNTHESIS OF ANTHRANILAMIDES BAYER SCHERING PHARMA AG (DE) 2008-10-02 US disclosed
US-20080242866-A1 SYNTHESIS OF ANTHRANILAMIDES BAYER SCHERING PHARMA AG (DE) 2008-10-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080242866-A1 SYNTHESIS OF ANTHRANILAMIDES ANTXR2, QTRT1, NQO2 FGFR4 4482/4885PIK3C3 3085/4885KDM4E 804/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.