SCHEMBL1402246

SCHEMBL1402246

COc1ccc(C=CC(=O)OC(CC(C)C)[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C)c(OC)c1OC

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 1/20 0.47
CYP1A1 P04798 3/20 0.46
CYP1B1 Q16678 3/20 0.46
CYP1A2 P05177 2/20 0.46
CYP2D6 P10635 2/20 0.46
CYP3A4 P08684 1/20 0.43
NPC1 O15118 1/20 0.42
LMNA P02545 1/20 0.42
TP53 P04637 1/20 0.42
RAB9A P51151 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
NFE2L2 Q16236 2/20 0.41
CHRNA7 P36544 1/20 0.40
ALOX5 P09917 1/20 0.38
ABCB1 P08183 1/20 0.38
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA4 P22748 1/20 0.36
CA6 P23280 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1402241 1.00 ABCG2 (0.47) ABCG2CYP1A1CYP1B1CYP1A2CYP2D6
SCHEMBL25335612 0.78 LMNA (0.56) NPC1LMNARAB9ASMN1; SMN2
SCHEMBL1883772 0.78 ABCG2 (0.62) ABCG2CYP1A1CYP1B1CYP1A2CYP2D6
SCHEMBL1883771 0.78 ABCG2 (0.62) ABCG2CYP1A1CYP1B1CYP1A2CYP2D6
SCHEMBL22500107 0.75 ABCG2 (0.59) ABCG2CYP1A1CYP1B1CYP1A2CYP2D6
SCHEMBL22500105 0.75 ABCG2 (0.59) ABCG2CYP1A1CYP1B1CYP1A2CYP2D6
SCHEMBL536156 0.75 LMNA (0.57) ABCG2CYP1A1CYP1B1CYP1A2CYP2D6
SCHEMBL536158 0.75 LMNA (0.57) ABCG2CYP1A1CYP1B1CYP1A2CYP2D6
SCHEMBL1878197 0.74 ABCG2 (0.58) ABCG2CYP1A1CYP1B1CYP1A2CYP2D6
SCHEMBL1878198 0.74 ABCG2 (0.58) ABCG2CYP1A1CYP1B1CYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 127 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2786735-A1 OIL-IN-WATER-TYPE EMULSION COSMETIC Kao Corporation (JP) 2014-10-08 EP claimed
JP-10203944-A None JP disclosed
JP-10212222-A None JP disclosed
US-20260108432-A1 WATER-IN-OIL EMULSION COSMETIC KAO CORPORATION (JP) 2026-04-23 US disclosed
US-12605315-B2 External skin preparation KAO CORPORATION (JP) 2026-04-21 US disclosed
US-12600821-B2 Crosslinked organosilicon resin, a method for producing same, and a cosmetic SHIN-ETSU CHEMICAL CO., LTD. (JP) 2026-04-14 US disclosed
EP-4717725-A1 ORGANOPOLYSILOXANE AND COSMETIC CONTAINING ORGANOPOLYSILOXANE SHIN-ETSU CHEMICAL CO., LTD. (JP) 2026-04-01 EP disclosed
EP-3822303-B1 CROSSLINKED ORGANOSILICON RESIN, METHOD FOR PRODUCING SAME, AND COSMETIC SHINETSU CHEMICAL CO (JP) 2026-03-04 EP disclosed
EP-4644466-A1 ORGANOPOLYSILOXANE, AND COSMETICS CONTAINING ORGANOPOLYSILOXANE SHIN-ETSU CHEMICAL CO., LTD. (JP) 2025-11-05 EP disclosed
EP-4643846-A1 COSMETIC PRODUCT SHIN-ETSU CHEMICAL CO., LTD. (JP) 2025-11-05 EP disclosed
US-8034891-B2 Polyether-modified organopolysiloxane, diorganopolysiloxane-polyether block copolymer, their production methods, and cosmetic preparation DOW CORNING TORAY COMPANY, LTD. (JP) 2011-10-11 US disclosed
EP-2292208-A1 EXTERNAL PREPARATION FOR SKIN Shiseido Company, Ltd. (JP) 2011-03-09 EP disclosed
US-20100310496-A1 METHOD OF PRODUCING AMINO ACID-MODIFIED ORGANOPOLYSILOXANE EMULSIONS DOW TORAY CO., LTD. (JP) 2010-12-09 US disclosed
US-20100036062-A1 Polyether-Modified Organopolysiloxane, Diorganopolysiloxane-Polyether Block Copolymer, Their Production Methods, and Cosmetic Preparation DOW TORAY CO., LTD. (JP) 2010-02-11 US disclosed
EP-2022812-A1 POLYETHER-MODIFIED ORGANOPOLYSILOXANE, DIORGANOPOLYSILOXANE-POLYETHER BLOCK COPOLYMER, THEIR PRODUCTION METHODS, AND COSMETIC PREPARATION Dow Corning Toray Co., Ltd. (JP) 2009-02-11 EP disclosed
US-20070116654-A1 Cosmetics SHISEIDO CO., LTD. 2007-05-24 US disclosed
EP-1661973-A1 PERFUME COMPOSITION FOR TEMPERATURE SENSE CONTROL, SENSE CONTROL ARTICLE, METHOD OF SENSE CONTROL AND PERFUME MAP Shiseido Co., Ltd. (JP) 2006-05-31 EP disclosed
EP-1514537-A2 ANTI-AGING AGENT AND COLLAGEN PRODUCTION PROMOTER SHISEIDO COMPANY LIMITED (JP) 2005-03-16 EP disclosed
JP-H10212222-A SUNSCREEN COSMETIC SHISEIDO CO LTD 1998-08-11 JP disclosed
JP-H10203944-A COSMETIC SHISEIDO CO LTD 1998-08-04 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12605315-B2 External skin preparation TLR5, CUTA, TLR3 ABCG2 4523/4885CYP1A1 2250/4885CYP1B1 3129/4885
US-20100310496-A1 METHOD OF PRODUCING AMINO ACID-MODIFIED ORGANOPOLYSILOXANE EMULSIONS DAO, BCAT2, IDUA ABCG2 3318/4885CYP1A1 2794/4885CYP1B1 2699/4885
US-12600821-B2 Crosslinked organosilicon resin, a method for producing same, and a cosmetic DEGS1, HACL2, GAR1 ABCG2 2951/4885CYP1A1 1416/4885CYP1B1 752/4885
US-20260108432-A1 WATER-IN-OIL EMULSION COSMETIC FOXM1, TYR, MITF ABCG2 1720/4885CYP1A1 170/4885CYP1B1 317/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.