Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13503810 | 0.86 | TSHR (0.36) | TSHRSIGMAR1OPRM1OPRL1TAAR1 | |
| SCHEMBL14174172 | 0.84 | SORT1 (0.38) | TSHRSIGMAR1ACHE | |
| SCHEMBL14028657 | 0.83 | ACHE (0.40) | TSHRSIGMAR1OPRM1ACHE | |
| SCHEMBL14028658 | 0.81 | SIGMAR1 (0.41) | SIGMAR1ACHE | |
| SCHEMBL25399422 | 0.68 | TSHR (0.40) | TSHR | |
| SCHEMBL25400656 | 0.67 | ADAM17 (0.38) | TSHR | |
| SCHEMBL21034771 | 0.66 | TACR1 (0.41) | TSHROPRM1OPRL1ACHEPOLB | |
| Propylene Oxide SCHEMBL335357 | 0.65 | TSHR (0.62) | TSHRTAAR1POLB | |
| Propylene Oxide SCHEMBL335355 | 0.65 | TSHR (0.62) | TSHRTAAR1POLB | |
| SCHEMBL19839312 | 0.65 | HTR2C (0.44) | TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449485-B2 | N-sulfonylurea apoptosis promoters | ABBOTT LABORATORIES INC. (US) | 2008-11-11 | — | — | US | disclosed |