Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14028657 | 0.92 | ACHE (0.40) | SIGMAR1ACHEMDM2 | |
| SCHEMBL13503873 | 0.86 | ACHE (0.33) | SIGMAR1ACHEKMT2A | |
| SCHEMBL14174172 | 0.85 | SORT1 (0.38) | SIGMAR1ACHEMDM2 | |
| SCHEMBL14028656 | 0.81 | TSHR (0.39) | SIGMAR1ACHE | |
| SCHEMBL2912160 | 0.72 | SIGMAR1 (0.38) | SIGMAR1 | |
| SCHEMBL14168752 | 0.66 | ITGB1 (0.40) | — | |
| SCHEMBL14884947 | 0.66 | TDP1 (0.38) | SIGMAR1 | |
| 3-[3-(4-Hydroxy-Phenyl)-Propyl]-5-Methyl-5-Phenyl-4,5-Dihydro-Isoxazole (Enantiomeric Mix) SCHEMBL2915705 | 0.65 | CALM1 (0.37) | SIGMAR1ACHE | |
| SCHEMBL12516740 | 0.63 | ALDH1A1 (0.40) | SIGMAR1MEN1KMT2A | |
| 5-Methyl-3-Phenethyl-5-Phenyl-4,5-Dihydroisoxazole (Enantiomeric Mix) SCHEMBL2921112 | 0.63 | ITGB1 (0.38) | SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449485-B2 | N-sulfonylurea apoptosis promoters | ABBOTT LABORATORIES INC. (US) | 2008-11-11 | — | — | US | disclosed |
| US-7358251-B2 | N-sulfonylurea apoptosis promoters | ABBOTT LABORATORIES (US) | 2008-04-15 | — | — | US | disclosed |