Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.48 |
| ▸ | EIF4H | Q15056 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | FADS1 | O60427 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14033666 | 0.84 | PABPC1 (0.48) | L3MBTL1PABPC1EIF4HMEN1KMT2A | |
| SCHEMBL4182229 | 0.80 | FAAH (0.43) | ALDH1A1MAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL14033102 | 0.78 | HSP90AA1 (0.47) | L3MBTL1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL4707557 | 0.78 | CYP19A1 (0.38) | L3MBTL1ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL30489100 | 0.78 | CYP19A1 (0.38) | L3MBTL1ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL14033098 | 0.77 | ACP3 (0.49) | L3MBTL1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL3747011 | 0.75 | KDM4E (0.48) | PABPC1EIF4HMEN1KMT2AALDH1A1 | |
| SCHEMBL29664507 | 0.75 | KDM4E (0.48) | PABPC1EIF4HMEN1KMT2AALDH1A1 | |
| SCHEMBL858300 | 0.75 | AXL (0.44) | KMT2AMAPTLMNAPOLB | |
| SCHEMBL30251313 | 0.74 | ALDH1A1 (0.40) | L3MBTL1ALDH1A1MAPTSMN1; SMN2HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809345-B2 | 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-08-19 | — | — | US | disclosed |
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |