Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.45 |
| ▸ | P4HB | P07237 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.44 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14033102 | 0.83 | HSP90AA1 (0.47) | L3MBTL1GAAKDRHSP90AA1P4HB | |
| SCHEMBL9876503 | 0.77 | PSMD14 (0.55) | L3MBTL1GAAHSP90AA1PSMD14COPS5 | |
| SCHEMBL14033666 | 0.76 | PABPC1 (0.48) | L3MBTL1SMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL28220687 | 0.74 | PSMD14 (0.52) | L3MBTL1GAAHSP90AA1PSMD14COPS5 | |
| SCHEMBL28037486 | 0.74 | PSMD14 (0.52) | L3MBTL1GAAHSP90AA1PSMD14COPS5 | |
| SCHEMBL17541536 | 0.74 | PSMD14 (0.52) | L3MBTL1GAAHSP90AA1PSMD14COPS5 | |
| SCHEMBL14033462 | 0.73 | CYP2C19 (0.47) | L3MBTL1LMNAMAPTTSHRKDM4E | |
| SCHEMBL9864313 | 0.72 | PSMD14 (0.42) | GAAHSP90AA1PSMD14COPS5SMN1; SMN2 | |
| SCHEMBL14034054 | 0.72 | LMNA (0.48) | L3MBTL1KDRSMN1; SMN2LMNATP53 | |
| SCHEMBL27536022 | 0.71 | PSMD14 (0.48) | L3MBTL1GAAHSP90AA1PSMD14COPS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |