Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 7/20 | 0.47 |
| ▸ | MMP9 | P14780 | 7/20 | 0.47 |
| ▸ | MMP1 | P03956 | 3/20 | 0.47 |
| ▸ | MMP3 | P08254 | 2/20 | 0.47 |
| ▸ | MMP13 | P45452 | 2/20 | 0.47 |
| ▸ | MMP14 | P50281 | 2/20 | 0.47 |
| ▸ | MMP12 | P39900 | 2/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MMP16 | P51512 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 3/20 | 0.44 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.43 |
| ▸ | PARL | Q9H300 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5881800 | 1.00 | MMP2 (0.47) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL4698467 | 0.86 | F10 (0.42) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL14040569 | 0.82 | F10 (0.52) | MMP2MMP9F10KMT2A | |
| SCHEMBL4701825 | 0.78 | F10 (0.54) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL4756093 | 0.77 | MMP2 (0.50) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL5882183 | 0.77 | F10 (0.44) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL4703108 | 0.75 | ALDH1A1 (0.48) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL14040571 | 0.75 | ALDH1A1 (0.48) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL4703238 | 0.75 | ALDH1A1 (0.48) | MMP2MMP9MMP1MMP3MMP13 | |
| Hydrochloric Acid SCHEMBL4703963 | 0.71 | F10 (0.42) | MMP2MMP9MMP1MMP3MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444202-B1 | NOVEL METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-10-15 | — | — | EP | disclosed |