Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | MMP2 | P08253 | 3/20 | 0.46 |
| ▸ | MMP1 | P03956 | 2/20 | 0.46 |
| ▸ | MMP13 | P45452 | 2/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703238 | 1.00 | ALDH1A1 (0.48) | ALDH1A1MMP2MMP1MMP13ADAMTS4 | |
| SCHEMBL4703108 | 1.00 | ALDH1A1 (0.48) | ALDH1A1MMP2MMP1MMP13ADAMTS4 | |
| SCHEMBL4699851 | 0.87 | MMP13 (0.42) | ALDH1A1MMP2MMP1MMP13MEN1 | |
| SCHEMBL5882266 | 0.79 | ALDH1A1 (0.44) | ALDH1A1MMP1MMP13MEN1MAPT | |
| SCHEMBL14040501 | 0.75 | MMP2 (0.47) | MMP2MMP1MMP13MMP14MEN1 | |
| SCHEMBL5881800 | 0.75 | MMP2 (0.47) | MMP2MMP1MMP13MMP14MEN1 | |
| SCHEMBL14040569 | 0.73 | F10 (0.52) | ALDH1A1MMP2KMT2ALMNASMN1; SMN2 | |
| SCHEMBL6846126 | 0.69 | TSHR (0.64) | ALDH1A1MMP2MMP1MMP13ADAMTS4 | |
| SCHEMBL4698467 | 0.69 | F10 (0.42) | MMP2MMP1MMP13ADAMTS4MMP14 | |
| SCHEMBL6846124 | 0.68 | TSHR (0.62) | ALDH1A1MMP2MMP1MMP13ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444202-B1 | NOVEL METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-10-15 | — | — | EP | disclosed |