Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 8/20 | 0.42 |
| ▸ | MMP2 | P08253 | 8/20 | 0.39 |
| ▸ | MMP9 | P14780 | 7/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | MMP14 | P50281 | 2/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | MMP16 | P51512 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | PARL | Q9H300 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5882183 | 0.94 | F10 (0.44) | F10MMP2MMP9ADAMTS4MMP1 | |
| Hydrochloric Acid SCHEMBL4703963 | 0.87 | F10 (0.42) | F10MMP2MMP9ADAMTS4MMP1 | |
| SCHEMBL4702692 | 0.87 | MMP2 (0.46) | F10MMP2MMP9MMP1MMP3 | |
| SCHEMBL4699851 | 0.86 | MMP13 (0.42) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL14040501 | 0.86 | MMP2 (0.47) | F10MMP2MMP9MMP1MMP3 | |
| SCHEMBL5881800 | 0.86 | MMP2 (0.47) | F10MMP2MMP9MMP1MMP3 | |
| SCHEMBL4700809 | 0.80 | MMP2 (0.45) | F10MMP2MMP9MMP1MMP3 | |
| SCHEMBL5882266 | 0.79 | ALDH1A1 (0.44) | MMP9MMP1MMP3MMP13MMP8 | |
| SCHEMBL4700381 | 0.75 | SLC18A3 (0.37) | MMP3MCL1 | |
| SCHEMBL14040569 | 0.70 | F10 (0.52) | F10MMP2MMP9F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444202-B1 | NOVEL METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-10-15 | — | — | EP | disclosed |