Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | GOT1 | P17174 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 7/20 | 0.40 |
| ▸ | RAB9A | P51151 | 7/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12954520 | 0.89 | GSK3B (0.43) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL14043342 | 0.87 | MARS1 (0.40) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL14418659 | 0.85 | MAPT (0.40) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL14418845 | 0.84 | ALDH1A1 (0.43) | NPC1RAB9AKMT2AMEN1AHR | |
| SCHEMBL14613288 | 0.82 | KMT2A (0.43) | KMT2AMEN1SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL14307169 | 0.82 | ALDH1A1 (0.38) | KMT2AMEN1KDM4ESMN1; SMN2GSK3B | |
| SCHEMBL14050826 | 0.82 | EPHX1 (0.46) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL13121929 | 0.80 | CDK2 (0.58) | GSK3B | |
| SCHEMBL14607070 | 0.79 | DRD2 (0.43) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL12954043 | 0.79 | GSK3B (0.42) | KDM4ESMN1; SMN2GSK3BHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130570-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |