Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGMT | P16455 | 4/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.40 |
| ▸ | PDE4A | P27815 | 6/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.39 |
| ▸ | CDK1 | P06493 | 5/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.38 |
| ▸ | CDK2 | P24941 | 5/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | PNP | P00491 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874737 | 0.77 | ADORA2A (0.56) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| Acetic Acid SCHEMBL4280720 | 0.74 | ADORA2B (0.57) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL6265343 | 0.73 | PDE4A (0.55) | MGMTADORA2AADORA2BPDE4APDE4B | |
| Acetic Acid SCHEMBL5323943 | 0.72 | MGMT (0.44) | MGMTADORA2AADORA2BPDE4APDE4B | |
| SCHEMBL2118527 | 0.72 | PDPK1 (0.44) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL5048181 | 0.71 | PNP (0.45) | MGMTADORA2AADORA2BPDE4APDE4B | |
| SCHEMBL667797 | 0.70 | PDE4A (0.60) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL27752224 | 0.70 | CYP2C19 (0.43) | MGMTCDK2CYP1A2PNPDPP4 | |
| SCHEMBL6265538 | 0.69 | MGMT (0.47) | MGMTADORA2AADORA2BPDE4APDE4B | |
| SCHEMBL28071828 | 0.69 | PNP (0.45) | MGMTADORA2AADORA2BPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10036066-B2 | In situ hybridization detection method | DAKO DENMARK A/S (DK) | 2018-07-31 | — | — | US | disclosed |
| US-9598720-B2 | Monomeric and polymeric linkers useful for conjugating biological molecules and other substances | DAKO DENMARK A/S (DK) | 2017-03-21 | — | — | US | disclosed |
| US-20160273035-A1 | IN SITU HYBRIDIZATION DETECTION METHOD | DAKO DENMARK A/S (DK) | 2016-09-22 | — | — | US | disclosed |
| EP-1919930-B1 | NEW NUCLEIC ACID BASE PAIRS | DAKO DENMARK AS (DK) | 2016-09-14 | — | — | EP | disclosed |
| US-9340824-B2 | Immunohistochemistry detection method | DAKO DENMARK A/S (DK) | 2016-05-17 | — | — | US | disclosed |
| US-9017992-B2 | In situ hybridization detection method | DAKO DENMARK A/S (DK) | 2015-04-28 | — | — | US | disclosed |
| EP-1910575-B1 | IMMUNOHISTOCHEMISTRY DETECTION METHOD | DAKO DENMARK AS (DK) | 2014-12-10 | — | — | EP | disclosed |
| US-20140315204-A1 | Immunohistochemistry Detection Method | DAKO DENMARK A/S (DK) | 2014-10-23 | — | — | US | disclosed |
| US-8741566-B2 | Immunohistochemistry and in situ hybridization detection method | DAKO DENMARK A/S (DK) | 2014-06-03 | — | — | US | disclosed |
| US-20140080145-A1 | Monomeric and Polymeric Linkers Useful For Conjugating Biological Molecules and Other Substances | DAKO DENMARK A/S (DK) | 2014-03-20 | — | — | US | disclosed |
| EP-1919930-A2 | NEW NUCLEIC ACID BASE PAIRS | Dako Denmark A/S (DK) | 2008-05-14 | — | — | EP | disclosed |
| EP-1920073-A2 | METHOD OF SIMULTANEOUSLY VISUALIZING MULTIPLE BIOLOGICAL TARGETS | Dako Denmark A/S (DK) | 2008-05-14 | — | — | EP | disclosed |
| EP-1910575-A2 | IMMUNOHISTOCHEMISTRY DETECTION METHOD | Dako Denmark A/S (DK) | 2008-04-16 | — | — | EP | disclosed |
| EP-1907592-A2 | MONOMERIC AND POLYMERIC LINKERS USEFUL FOR CONJUGATING BIOLOGICAL MOLECULES AND OTHER SUBSTANCES | Dako Denmark A/S (DK) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007031874-A9 | METHOD OF SIMULTANEOUSLY VISUALIZING MULTIPLE BIOLOGICAL TARGETS | DAKO DENMARK AS (DK) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007045998-A2 | NEW NUCLEIC ACID BASE PAIRS | DAKO DENMARK A/S (US) | 2007-04-26 | — | — | WO | disclosed |
| WO-2007031874-A2 | METHOD OF SIMULTANEOUSLY VISUALIZING MULTIPLE BIOLOGICAL TARGETS | DAKO DENMARK A/S (US) | 2007-03-22 | — | — | WO | disclosed |
| WO-2007026252-A2 | IN SITU HYBRIDIZATION DETECTION METHOD | DAKO DENMARK A/S (US) | 2007-03-08 | — | — | WO | disclosed |
| WO-2007023390-A2 | IMMUNOHISTOCHEMISTRY DETECTION METHOD | DAKO DENMARK A/S (US) | 2007-03-01 | — | — | WO | disclosed |
| WO-2007015168-A2 | MONOMERIC AND POLYMERIC LINKERS USEFUL FOR CONJUGATING BIOLOGICAL MOLECULES AND OTHER SUBSTANCES | DAKO DENMARK A/S (US) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140080145-A1 | Monomeric and Polymeric Linkers Useful For Conjugating Biological Molecules and Other Substances | PCNA, DCLRE1A, TK1 | MGMT 203/4885ADORA2A 2722/4885ADORA2B 3693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.