Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14544032 | 0.81 | DRD2 (0.39) | DRD2DRD4DRD3DRD1DRD5 | |
| SCHEMBL14044941 | 0.75 | PSEN1 (0.49) | — | |
| SCHEMBL14019411 | 0.70 | NR3C1 (0.36) | OPRM1OPRL1KCNH2MEN1KMT2A | |
| SCHEMBL14612108 | 0.61 | MEN1 (0.32) | MEN1KMT2ALMNACYP1A2CYP2C9 | |
| SCHEMBL14612069 | 0.61 | LMNA (0.40) | KDM4EALDH1A1LMNAMAPTALOX15 | |
| SCHEMBL630379 | 0.60 | CYP19A1 (0.60) | MEN1KMT2ALMNACYP2D6MAPT | |
| SCHEMBL7685977 | 0.59 | KMT2A (0.35) | MEN1KMT2AGAAKDM4EUSP2 | |
| SCHEMBL11248429 | 0.59 | MEN1 (0.50) | KCNH2MEN1KMT2AGAAKDM4E | |
| SCHEMBL30666908 | 0.58 | KDM1A (0.43) | MEN1KMT2ACYP2C9 | |
| SCHEMBL26371283 | 0.58 | CYP19A1 (0.56) | OPRM1MEN1GLAKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435748-B2 | Gamma-secretase inhibitors | MERCK SHARP & DOHME LTD. (GB) | 2008-10-14 | — | — | US | disclosed |
| US-20070088063-A1 | Gamma-secretase inhibitors | CASTRO PINEIRO JOSE L | 2007-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070088063-A1 | Gamma-secretase inhibitors | BACE1, BACE2, PSEN1 | OPRM1 4240/4885OPRL1 3704/4885KCNH2 4469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.