Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 2/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.65 |
| ▸ | APP | P05067 | 9/20 | 0.61 |
| ▸ | P4HB | P07237 | 4/20 | 0.51 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | TTR | P02766 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1404874 | 1.00 | IAPP (0.65) | IAPPPTGS1APPP4HBCXCL12 | |
| SCHEMBL11971417 | 0.87 | APP (0.60) | IAPPPTGS1APPP4HBKDM4E | |
| SCHEMBL11971419 | 0.87 | APP (0.60) | IAPPPTGS1APPP4HBKDM4E | |
| SCHEMBL16141410 | 0.84 | IAPP (0.51) | IAPPPTGS1APPGLATDP1 | |
| SCHEMBL11999778 | 0.82 | APP (0.56) | IAPPPTGS1APPP4HBCXCL12 | |
| SCHEMBL3560692 | 0.81 | IAPP (0.51) | IAPPPTGS1APPKDM4EGLA | |
| SCHEMBL3560696 | 0.81 | IAPP (0.51) | IAPPPTGS1APPKDM4EGLA | |
| SCHEMBL1881134 | 0.79 | IAPP (1.00) | IAPPPTGS1APPKDM4EHSD17B10 | |
| SCHEMBL1881133 | 0.79 | IAPP (1.00) | IAPPPTGS1APPKDM4EHSD17B10 | |
| SCHEMBL29364807 | 0.79 | IAPP (1.00) | IAPPPTGS1APPKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079747-B1 | HETEROCYCLIC COMPOUNDS USEFUL AS ANABOLIC AGENTS FOR LIVESTOCK ANIMALS | PFIZER LTD (GB) | 2011-03-09 | — | — | EP | disclosed |
| US-20080161288-A1 | COMPOUNDS | PFIZER INC. | 2008-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161288-A1 | COMPOUNDS | ADRB2, ADRB1, ADRA2C | IAPP 1485/4885PTGS1 1214/4885APP 1746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.