Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL9 | O00512 | 5/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.43 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.42 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12953316 | 0.90 | JAK2 (0.47) | BCL9CTNNB1JAK2JAK1TYK2 | |
| SCHEMBL12953214 | 0.89 | JAK2 (0.45) | BCL9CTNNB1JAK2JAK1TYK2 | |
| SCHEMBL14050953 | 0.88 | JAK2 (0.44) | BCL9CTNNB1JAK2JAK1TYK2 | |
| SCHEMBL14541612 | 0.81 | TRPV3 (0.45) | JAK2JAK1PDE4BUSP30 | |
| SCHEMBL14050894 | 0.81 | AADAT (0.48) | MEN1KMT2ANPSR1 | |
| SCHEMBL12953168 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AUSP30TRPC3 | |
| SCHEMBL13305223 | 0.78 | TRPC3 (0.44) | BCL9CTNNB1JAK2JAK1TYK2 | |
| SCHEMBL12953174 | 0.78 | TRPC3 (0.52) | SMN1; SMN2NPC1RAB9AUSP30TRPC3 | |
| SCHEMBL13490506 | 0.78 | JAK2 (0.55) | JAK2JAK1TYK2JAK3SMN1; SMN2 | |
| SCHEMBL2876671 | 0.77 | ENPP2 (0.49) | BCL9CTNNB1JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130569-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |