Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.50 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | HTR2B | P41595 | 3/20 | 0.34 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | MPI | P34949 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1877071 | 0.81 | NOTUM (0.55) | NOTUMPNMTHTR2AHTR2CHTR2B | |
| SCHEMBL29599871 | 0.81 | NOTUM (0.55) | NOTUMPNMTHTR2AHTR2CHTR2B | |
| SCHEMBL1405509 | 0.81 | NOTUM (0.36) | NOTUMNISCHDRD2DRD4CDK2 | |
| SCHEMBL30768024 | 0.81 | NOTUM (0.36) | NOTUMNISCHDRD2DRD4CDK2 | |
| SCHEMBL23384792 | 0.76 | UHRF1 (0.34) | NOTUMNISCHCDK2PARP1PARP10 | |
| SCHEMBL26431777 | 0.76 | ALDH1A1 (0.34) | NOTUMALDH1A1MAPTCDK2PARP1 | |
| SCHEMBL24713940 | 0.76 | NOTUM (0.33) | NOTUMCDK2PARP1PARP10 | |
| SCHEMBL32669251 | 0.74 | PARP10 (0.51) | NOTUMHTTPTK2BCDK2PARP1 | |
| SCHEMBL31161777 | 0.72 | ERN1 (0.39) | NOTUMCDK2PARP1PARP10 | |
| SCHEMBL23977600 | 0.72 | GFER (0.32) | NOTUMHTR2AHTR2CHTR2BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049557-B1 | 1- (-D-GLYCOPYRANOSYL) - 3 - (4-CYCLOPROPYLPHENYLMETHYL) - 4 - HALOGENO INDOLE DERIVATIVES AND USE THEREOF AS SGLT INHIBITORS. | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-03-09 | — | — | EP | disclosed |
| US-7851617-B2 | Indole derivatives | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-12-14 | — | — | US | disclosed |
| EP-2049557-A1 | 1- (-D-GLYCOPYRANOSYL) - 3 - (4-CYCLOPROPYLPHENYLMETHYL) - 4 - HALOGENO INDOLE DERIVATIVES AND USE THEREOF AS SGLT INHIBITORS. | Mitsubishi Tanabe Pharma Corporation (JP) | 2009-04-22 | — | — | EP | disclosed |
| US-20080027122-A1 | Indole derivatives | TANABE SEIYAKU CO., LTD. | 2008-01-31 | — | — | US | disclosed |
| WO-2008013322-A1 | 1- (-D-GLYCOPYRANOSYL) - 3 - (4-CYCLOPROPYLPHENYLMETHYL) - 4 - HALOGENO INDOLE DERIVATIVES AND USE THEREOF AS SGLT INHIBITORS. | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2008-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027122-A1 | Indole derivatives | SLC5A1, SLC5A2, SLC5A11 | NOTUM 3579/4885PNMT 563/4885HTR2A 155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.