Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29599871 | 1.00 | NOTUM (0.55) | NOTUMHTR2AHTR2CHTR2BMEN1 | |
| SCHEMBL6185822 | 0.87 | MAPT (0.50) | NOTUMHTR2AHTR2CHTR2BMEN1 | |
| Indoline SCHEMBL22344733 | 0.84 | NOTUM (0.46) | NOTUMHTR2AHTR2CHTR2BMEN1 | |
| SCHEMBL1405476 | 0.81 | NOTUM (0.50) | NOTUMHTR2AHTR2CHTR2BMEN1 | |
| SCHEMBL7038840 | 0.78 | NOTUM (0.42) | NOTUMHTR2AHTR2CHTR2BMEN1 | |
| SCHEMBL31161303 | 0.78 | NOTUM (0.42) | NOTUMHTR2AHTR2CHTR2BMEN1 | |
| SCHEMBL20939380 | 0.78 | NOTUM (0.42) | NOTUMHTR2AHTR2CHTR2BMEN1 | |
| SCHEMBL9514990 | 0.75 | MEN1 (0.56) | NOTUMHTR2AHTR2CHTR2BMEN1 | |
| SCHEMBL27732858 | 0.75 | MEN1 (0.49) | NOTUMMEN1KMT2APNMTDRD2 | |
| SCHEMBL27670186 | 0.74 | ALDH1A1 (0.48) | NOTUMHTR2AHTR2CHTR2BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3877364-B1 | ROCK KINASE INHIBITORS | Cervello Therapeutics LLC (US) | 2024-08-21 | — | — | EP | disclosed |
| US-11912719-B2 | Substituted isoquinolines as rock kinase inhibitors | CERVELLO THERAPEUTICS, LLC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-11912719-B2 | Substituted isoquinolines as rock kinase inhibitors | CERVELLO THERAPEUTICS, LLC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-11912719-B2 | Substituted isoquinolines as rock kinase inhibitors | CERVELLO THERAPEUTICS, LLC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-20220119406-A1 | SUBSTITUTED ISOQUINOLINES AS ROCK KINASE INHIBITORS | Cervello Therapeutics LLC (US) | 2022-04-21 | — | — | US | disclosed |
| US-20220119406-A1 | SUBSTITUTED ISOQUINOLINES AS ROCK KINASE INHIBITORS | Cervello Therapeutics LLC (US) | 2022-04-21 | — | — | US | disclosed |
| US-11248004-B2 | Substituted isoquinolines as rock kinase inhibitors | CERVELLO THERAPEUTICS, LLC. (US) | 2022-02-15 | — | — | US | disclosed |
| US-11248004-B2 | Substituted isoquinolines as rock kinase inhibitors | CERVELLO THERAPEUTICS, LLC. (US) | 2022-02-15 | — | — | US | disclosed |
| EP-3877364-A1 | ROCK KINASE INHIBITORS | Cervello Therapeutics, LLC (US) | 2021-09-15 | — | — | EP | disclosed |
| CN-113227054-A | ROCK kinase inhibitors | 切尔韦洛治疗有限责任公司 | 2021-08-06 | — | — | CN | disclosed |
| US-10745381-B2 | Substituted isoquinolines and phthalazines as rock kinase inhibitors | CERVELLO THERAPEUTICS, LLC. (US) | 2020-08-18 | — | — | US | disclosed |
| US-20200140412-A1 | ROCK KINASE INHIBITORS | CERVELLO THERAPEUTICS, LLC. | 2020-05-07 | — | — | US | disclosed |
| US-20200140412-A1 | ROCK KINASE INHIBITORS | CERVELLO THERAPEUTICS, LLC. | 2020-05-07 | — | — | US | disclosed |
| US-9580426-B2 | Compounds that expand hematopoietic stem cells | NOVARTIS AG (CH) | 2017-02-28 | — | — | US | disclosed |
| US-20140114070-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-04-24 | — | — | US | disclosed |
| US-7935674-B2 | Indole derivatives | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-05-03 | — | — | US | disclosed |
| CN-101111492-B | Indole derivatives | TANABE SEIYAKU CO | 2010-09-22 | — | — | CN | disclosed |
| US-20090258921-A1 | INDOLE DERIVATIVES | NOMURA SUMIHIRO | 2009-10-15 | — | — | US | disclosed |
| US-20080119422-A1 | Indole Derivatives | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2008-05-22 | — | — | US | disclosed |
| CN-101111492-A | Indole derivatives | TANABE SEIYAKU CO (JP) | 2008-01-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258921-A1 | INDOLE DERIVATIVES | IDO1, TPH1, NAT1 | NOTUM 4149/4885HTR2A 23/4885HTR2C 18/4885 |
| US-10745381-B2 | Substituted isoquinolines and phthalazines as rock kinase inhibitors | ROCK1, ROCK2, CIT | NOTUM 2976/4885HTR2A 1426/4885HTR2C 1931/4885 |
| US-11248004-B2 | Substituted isoquinolines as rock kinase inhibitors | ROCK1, ROCK2, CIT | NOTUM 2655/4885HTR2A 1676/4885HTR2C 1836/4885 |
| US-11912719-B2 | Substituted isoquinolines as rock kinase inhibitors | ROCK1, ROCK2, CIT | NOTUM 2655/4885HTR2A 1676/4885HTR2C 1836/4885 |
| US-20200140412-A1 | ROCK KINASE INHIBITORS | ROCK1, ROCK2, RHOA | NOTUM 2653/4885HTR2A 3280/4885HTR2C 3778/4885 |
| US-20140114070-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | CD47, HCLS1, CD74 | NOTUM 4840/4885HTR2A 4652/4885HTR2C 4674/4885 |
| US-20080119422-A1 | Indole Derivatives | IDO1, TPH1, NAT1 | NOTUM 4149/4885HTR2A 23/4885HTR2C 18/4885 |
| US-20220119406-A1 | SUBSTITUTED ISOQUINOLINES AS ROCK KINASE INHIBITORS | ROCK1, ROCK2, CIT | NOTUM 2655/4885HTR2A 1676/4885HTR2C 1836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.