Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD40 | P25942 | 3/20 | 0.56 |
| ▸ | CD40LG | P29965 | 3/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TTR | P02766 | 1/20 | 0.48 |
| ▸ | FABP4 | P15090 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6242038 | 0.85 | CD40 (0.61) | CD40CD40LGMEN1KMT2AALDH1A1 | |
| SCHEMBL14149590 | 0.78 | TRPV1 (0.53) | ACHEMAOBMEN1KMT2AALDH1A1 | |
| SCHEMBL19020654 | 0.78 | CD40 (0.69) | CD40CD40LGMEN1KMT2AALDH1A1 | |
| SCHEMBL11511725 | 0.77 | CD40 (0.69) | CD40CD40LGMEN1KMT2AALDH1A1 | |
| SCHEMBL19020634 | 0.74 | CD40 (0.77) | CD40CD40LGMEN1KMT2ATTR | |
| SCHEMBL19021224 | 0.74 | CD40 (0.92) | CD40CD40LGACHEMEN1KMT2A | |
| SCHEMBL11759224 | 0.74 | TTR (0.59) | CD40CD40LGALDH1A1TTRFABP4 | |
| SCHEMBL11466232 | 0.73 | TTR (0.52) | CD40CD40LGMEN1KMT2ATTR | |
| SCHEMBL14059013 | 0.72 | TRPV1 (0.58) | ACHEMAOBMEN1KMT2AALDH1A1 | |
| SCHEMBL19020632 | 0.72 | CD40 (1.00) | CD40CD40LGMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012162365-A1 | SUBSTITUTED SULFONAMIDES USEFUL AS ANTIAPOPTOTIC BCL INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-11-29 | — | — | WO | disclosed |