Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | AGXT | P21549 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27953793 | 0.84 | CNR2 (0.52) | CNR2LMNAPIK3C3ARTSHR | |
| SCHEMBL27943408 | 0.83 | DRD2 (0.45) | TSHRAGXTABL1MAPTALDH1A1 | |
| SCHEMBL27943391 | 0.81 | AR (0.39) | ARALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL27943382 | 0.81 | CNR2 (0.39) | CNR2TSHRALDH1A1CYP1A2SMN1; SMN2 | |
| SCHEMBL20143012 | 0.76 | PRKDC (0.45) | LMNATSHRKMOMAPTALDH1A1 | |
| SCHEMBL3947775 | 0.76 | LMNA (0.50) | LMNAARTSHRAGXTKMO | |
| SCHEMBL27943552 | 0.74 | PKM (0.36) | CYP1A2HTTRAB9AKMT2AGAA | |
| SCHEMBL27943399 | 0.74 | CREBBP (0.38) | CNR2TSHRALDH1A1MEN1CYP1A2 | |
| SCHEMBL1570038 | 0.74 | AR (0.44) | LMNAARMAPTCYP1A2HTT | |
| SCHEMBL1569971 | 0.72 | CHEK1 (0.46) | ALDH1A1CYP1A2HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105209463-A | 2-aminopyrido[4,3-d]pyrimidin-5-one derivatives and their use as wee-1 inhibitors | ALMAC DISCOVERY LTD | 2015-12-30 | — | — | CN | claimed |
| CN-103703005-A | Tricyclic inhibitors of kinases | ABBOTT LAB | 2014-04-02 | — | — | CN | claimed |
| CN-105209463-A | 2-aminopyrido[4,3-d]pyrimidin-5-one derivatives and their use as wee-1 inhibitors | ALMAC DISCOVERY LTD | 2015-12-30 | — | — | CN | disclosed |
| CN-103703005-A | Tricyclic inhibitors of kinases | ABBOTT LAB | 2014-04-02 | — | — | CN | disclosed |