Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 9/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | AGXT | P21549 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27943408 | 0.83 | DRD2 (0.45) | ADRA2CAGXTHTR3AHTR6 | |
| SCHEMBL14060936 | 0.82 | DHFR (0.43) | ADRA2CRPS6KA3AGXTHTR3AHTR6 | |
| SCHEMBL28809786 | 0.79 | SMN1; SMN2 (0.33) | HRH4RPS6KA3HTR3AMAPK14 | |
| SCHEMBL14060358 | 0.76 | HRH4 (0.47) | ADRA2CHRH4 | |
| SCHEMBL27997678 | 0.76 | HTR6 (0.46) | ADRA2CAGXTHTR3AMAPK14HTR6 | |
| SCHEMBL3578032 | 0.75 | NPC1 (0.42) | ADRA2CHTR3A | |
| SCHEMBL27953736 | 0.74 | ALDH1A1 (0.51) | — | |
| SCHEMBL14059902 | 0.73 | CYP1A2 (0.47) | ADRA2CHRH4AGXTHTR3AHTR6 | |
| SCHEMBL29036651 | 0.72 | ADRA2C (0.58) | ADRA2CHRH4HTR3A | |
| SCHEMBL27997451 | 0.71 | HTR6 (0.49) | ADRA2CHRH4AGXTHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103703005-A | Tricyclic inhibitors of kinases | ABBOTT LAB | 2014-04-02 | — | — | CN | claimed |
| EP-2681221-A1 | TRICYCLIC INHIBITORS OF KINASES | AbbVie Inc. (US) | 2014-01-08 | — | — | EP | claimed |
| WO-2012161812-A1 | TRICYCLIC INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2012-11-29 | — | — | WO | claimed |
| CN-103703005-A | Tricyclic inhibitors of kinases | ABBOTT LAB | 2014-04-02 | — | — | CN | disclosed |
| EP-2681221-A1 | TRICYCLIC INHIBITORS OF KINASES | AbbVie Inc. (US) | 2014-01-08 | — | — | EP | disclosed |
| WO-2012161812-A1 | TRICYCLIC INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2012-11-29 | — | — | WO | disclosed |