Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3600688 | 0.84 | HTR2A (0.57) | — | |
| SCHEMBL22254776 | 0.84 | HRH3 (0.62) | CCR3MAOBHRH3L3MBTL1 | |
| SCHEMBL3594852 | 0.83 | CCR3 (0.73) | CCR3 | |
| Hydrochloric Acid SCHEMBL30843800 | 0.83 | KCNH2 (0.56) | — | |
| Hydrochloric Acid SCHEMBL23124024 | 0.82 | CCR3 (0.71) | CCR3 | |
| SCHEMBL14100275 | 0.81 | SPHK1 (0.65) | CCR3MAOBHRH3 | |
| SCHEMBL4700505 | 0.81 | HRH3 (0.62) | CCR3HRH3L3MBTL1 | |
| SCHEMBL3602416 | 0.80 | MAOB (0.56) | CCR3MAOBHRH3 | |
| SCHEMBL3590302 | 0.80 | SIGMAR1 (0.69) | HRH3 | |
| SCHEMBL7407241 | 0.80 | CCR3 (0.82) | CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8507528-B2 | 2-alkyl-indazole compounds for the treatment of certain cns-related disorders | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2013-08-13 | — | — | US | disclosed |
| CN-101558057-B | 2 -alkyl- indazole compounds for the treatment of certain cns-related disorders | ACRAF | 2013-05-01 | — | — | CN | disclosed |
| US-8415476-B2 | Indazole having analgesic activity | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2013-04-09 | — | — | US | disclosed |
| EP-2099780-B1 | 2 -ALKYL- INDAZOLE COMPOUNDS FOR THE TREATMENT OF CERTAIN CNS-RELATED DISORDERS | ACRAF (IT) | 2013-01-09 | — | — | EP | disclosed |
| EP-1622892-B1 | INDAZOLES HAVING ANALGESIC ACTIVITY | ACRAF (IT) | 2011-03-09 | — | — | EP | disclosed |
| US-20100094015-A1 | INDAZOLE HAVING ANALGESIC ACTIVITY | AZIENDE CHIM. RIUN. ANGEL. FRA. A.C.R.A.F. S.P.A. (IT) | 2010-04-15 | — | — | US | disclosed |
| US-20100056573-A1 | 2-ALKYL-INDAZOLE COMPOUNDS FOR THE TREATMENT OF CERTAIN CNS-RELATED DISORDERS | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2010-03-04 | — | — | US | disclosed |
| US-7662836-B2 | Indazole having analgesic activity | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2010-02-16 | — | — | US | disclosed |
| US-7638534-B2 | Use of indazole derivatives for the treatment of neuropathic pain | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2009-12-29 | — | — | US | disclosed |
| CN-101558057-A | 2 -alkyl- indazole compounds for the treatment of certain cns-related disorders | ACRAF (IT) | 2009-10-14 | — | — | CN | disclosed |
| EP-2099780-A1 | 2 -ALKYL- INDAZOLE COMPOUNDS FOR THE TREATMENT OF CERTAIN CNS-RELATED DISORDERS | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (IT) | 2009-09-16 | — | — | EP | disclosed |
| CN-100427089-C | Use of indazole derivatives for the treatment of neuropathic pain | ACRAF (IT) | 2008-10-22 | — | — | CN | disclosed |
| WO-2008061688-A1 | 2 -ALKYL- INDAZOLE COMPOUNDS FOR THE TREATMENT OF CERTAIN CNS-RELATED DISORDERS | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2008-05-29 | — | — | WO | disclosed |
| US-20070010555-A1 | Indazole having analgesic activity | AZIENDE CHIM. RUIN. ANGEL. FRA. A.C.R.A.F. S.P.A. (IT) | 2007-01-11 | — | — | US | disclosed |
| EP-1646387-B1 | USE OF INDAZOLE DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | ACRAF (IT) | 2006-11-15 | — | — | EP | disclosed |
| US-20060183775-A1 | Use of indazole derivatives for the treatment of neuropathic pain | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO S.P.A. (IT) | 2006-08-17 | — | — | US | disclosed |
| CN-1809356-A | Use of indazole derivatives for the treatment of neuropathic pain | ACRAF (IT) | 2006-07-26 | — | — | CN | disclosed |
| EP-1646387-A1 | USE OF INDAZOLE DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (IT) | 2006-04-19 | — | — | EP | disclosed |
| WO-2005013989-A1 | USE OF INDAZOLE DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R..A.F. S.P.A. (IT) | 2005-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056573-A1 | 2-ALKYL-INDAZOLE COMPOUNDS FOR THE TREATMENT OF CERTAIN CNS-RELATED DISORDERS | CYP11B2, CYP1A2, INA | CCR3 2769/4885MAOB 65/4885HRH3 348/4885 |
| US-20060183775-A1 | Use of indazole derivatives for the treatment of neuropathic pain | SCN3A, OPRD1, SCN1A | CCR3 350/4885MAOB 1340/4885HRH3 55/4885 |
| US-20100094015-A1 | INDAZOLE HAVING ANALGESIC ACTIVITY | OPRK1, OPRD1, ACHE | CCR3 870/4885MAOB 351/4885HRH3 360/4885 |
| US-20070010555-A1 | Indazole having analgesic activity | ACHE, CYP3A43, RPL35A | CCR3 498/4885MAOB 1095/4885HRH3 196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.