Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | FOLH1 | Q04609 | 13/20 | 0.49 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15290484 | 0.91 | FOLH1 (0.54) | SMN1; SMN2FOLH1 | |
| SCHEMBL14063688 | 0.77 | FOLH1 (0.59) | FOLH1 | |
| SCHEMBL13057107 | 0.77 | FOLH1 (0.55) | SMN1; SMN2FOLH1SIRT5SIRT2SIRT1 | |
| SCHEMBL8396195 | 0.75 | SMN1; SMN2 (0.61) | SMN1; SMN2FOLH1SIRT5SIRT1ALB | |
| SCHEMBL19352030 | 0.74 | FOLH1 (0.73) | SMN1; SMN2FOLH1ALB | |
| SCHEMBL23983058 | 0.73 | FOLH1 (0.48) | SMN1; SMN2FOLH1SIRT5SIRT2SIRT1 | |
| SCHEMBL14996216 | 0.73 | HRH2 (0.41) | SMN1; SMN2 | |
| SCHEMBL15328463 | 0.73 | POLB (0.54) | SMN1; SMN2FOLH1 | |
| SCHEMBL14063681 | 0.73 | NOD1 (0.53) | FOLH1ALB | |
| SCHEMBL15762848 | 0.73 | FOLH1 (0.60) | SMN1; SMN2FOLH1SIRT5SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130177961-A1 | MULTI-ARMED, MONOFUNCTIONAL, AND HYDROLYTICALLY STABLE DERIVATIVES OF POLY(ETHYLENE GLYCOL) AND RELATED POLYMERS FOR MODIFICATION OF SURFACES AND MOLECULES | NEKTAR THERAPEUTICS (US) | 2013-07-11 | — | — | US | disclosed |
| US-7419600-B2 | Method for purifying a branched water-soluble polymer | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2008-09-02 | — | — | US | disclosed |