Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PORCN | Q9H237 | 2/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | WNT3A | P56704 | 2/20 | 0.47 |
| ▸ | SREBF2 | Q12772 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | F11 | P03951 | 2/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3614814 | 0.88 | PORCN (0.48) | PORCNPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL11178821 | 0.84 | KIF11 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL11189054 | 0.82 | KIT (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12442177 | 0.81 | PORCN (0.70) | PORCNPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4707261 | 0.79 | F11 (0.49) | PORCNPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL16927500 | 0.78 | PORCN (0.47) | PORCNPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14063616 | 0.78 | LMNA (0.52) | PORCNPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7251623 | 0.76 | SMN1; SMN2 (0.72) | CYP2D6MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL31555358 | 0.74 | CYP1A2 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL24220194 | 0.74 | PRKCI (0.35) | WNT3ASREBF2MCL1ALDH1A1PRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429604-B2 | Six-membered heterocycles useful as serine protease inhibitors | BRISTOL MYERS SQUIBB COMPANY (US) | 2008-09-30 | — | — | US | disclosed |